| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKG1 | CFTR | Ser660 | FSAERRNsILTETLH | phosphorylation up-regulates | 10581361 | SIGNOR-72712 |
| PRKACA | CFTR | Ser660 | FSAERRNsILTETLH | phosphorylation up-regulates | 1716180 | SIGNOR-21312 |
| PRKG1 | CFTR | Ser660 | FSAERRNsILTETLH | phosphorylation up-regulates | 1377674 | SIGNOR-18237 |
| PRKACA | CFTR | Ser660 | FSAERRNsILTETLH | phosphorylation up-regulates activity | 1377674 | SIGNOR-250349 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKG1 | phosphorylation up-regulates → | CFTR PSer660 | phosphorylation up-regulates → | CFTR | 10581361 | SIGNOR-72712 |
| PRKACA | phosphorylation up-regulates → | CFTR PSer660 | phosphorylation up-regulates → | CFTR | 1716180 | SIGNOR-21312 |
| PRKG1 | phosphorylation up-regulates → | CFTR PSer660 | phosphorylation up-regulates → | CFTR | 1377674 | SIGNOR-18237 |
| PRKACA | phosphorylation up-regulates → | CFTR PSer660 | phosphorylation up-regulates → | CFTR | 1377674 | SIGNOR-250349 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKG1 | phosphorylation → up-regulates | CFTR | SIGNOR-72712 |
| PRKACA | phosphorylation → up-regulates | CFTR | SIGNOR-21312 |
| PRKG1 | phosphorylation → up-regulates | CFTR | SIGNOR-18237 |
| PRKACA | phosphorylation → up-regulates activity | CFTR | SIGNOR-250349 |
