| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EEF2K | EEF2 | Thr59 | GETRFTDtRKDEQER | phosphorylation down-regulates | 8386634 | SIGNOR-38556 |
| PPP2CA | EEF2 | Thr59 | GETRFTDtRKDEQER | dephosphorylation up-regulates | 8386634 | SIGNOR-38566 |
| EEF2K | EEF2 | Thr59 | GETRFTDtRKDEQER | phosphorylation down-regulates | 2261989 | SIGNOR-22928 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EEF2K | phosphorylation up-regulates → | EEF2 PThr59 | phosphorylation down-regulates ⊣ | EEF2 | 8386634 | SIGNOR-38556 |
| PPP2CA | dephosphorylation down-regulates ⊣ | EEF2 PThr59 | dephosphorylation down-regulates ⊣ | EEF2 | 8386634 | SIGNOR-38566 |
| EEF2K | phosphorylation up-regulates → | EEF2 PThr59 | phosphorylation down-regulates ⊣ | EEF2 | 2261989 | SIGNOR-22928 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EEF2K | phosphorylation down-regulates | EEF2 | SIGNOR-38556 |
| PPP2CA | dephosphorylation → up-regulates | EEF2 | SIGNOR-38566 |
| EEF2K | phosphorylation down-regulates | EEF2 | SIGNOR-22928 |
