| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | GYS1 | Ser649 | VPPSPSLsRHSSPHQ | phosphorylation down-regulates activity | 6772446 | SIGNOR-253007 |
| GSK3B | GYS1 | Ser649 | VPPSPSLsRHSSPHQ | phosphorylation down-regulates activity | 11427888 | SIGNOR-251240 |
| CSNK2A1 | GYS1 | Ser649 | VPPSPSLsRHSSPHQ | phosphorylation unknown | 2117608 | SIGNOR-250880 |
| GSK3A | GYS1 | Ser641 | YRYPRPAsVPPSPSL | phosphorylation down-regulates | 14593110 | SIGNOR-118927 |
| PRKACA | GYS1 | Ser8 | MPLNRTLsMSSLPGL | phosphorylation unknown | 2117608 | SIGNOR-249988 |
| PPP1R3A | GYS1 | – | dephosphorylation up-regulates | 8250835 | SIGNOR-37301 | |
| CSNK2A1 | GYS1 | Ser698 | PEWPRRAsCTSSTSG | phosphorylation unknown | 2117608 | SIGNOR-250883 |
| CSNK2A1 | GYS1 | Ser645 | RPASVPPsPSLSRHS | phosphorylation unknown | 2117608 | SIGNOR-250879 |
| PRKACA | GYS1 | Ser8 | MPLNRTLsMSSLPGL | phosphorylation down-regulates activity | 6263629 | SIGNOR-253008 |
| PASK | GYS1 | – | phosphorylation down-regulates activity | 16275910 | SIGNOR-245866 | |
| CSNK2A1 | GYS1 | Ser653 | PSLSRHSsPHQSEDE | phosphorylation unknown | 2117608 | SIGNOR-250881 |
| AMPK | GYS1 | Ser8 | MPLNRTLsMSSLPGL | phosphorylation down-regulates activity | 22233421 | SIGNOR-263102 |
| GSK3B | GYS1 | Ser653 | PSLSRHSsPHQSEDE | phosphorylation down-regulates activity | 11427888 | SIGNOR-251241 |
| GSK3B | GYS1 | Ser641 | YRYPRPAsVPPSPSL | phosphorylation down-regulates activity | 6772446 | SIGNOR-253005 |
| DYRK1A | GYS1 | Ser641 | YRYPRPAsVPPSPSL | phosphorylation down-regulates activity | 14593110 | SIGNOR-260632 |
| CSNK2A1 | GYS1 | Ser10 | LNRTLSMsSLPGLED | phosphorylation unknown | 2117608 | SIGNOR-250878 |
| DYRK1B | GYS1 | Ser641 | YRYPRPAsVPPSPSL | phosphorylation down-regulates activity | 14593110 | SIGNOR-260633 |
| PRKACA | GYS1 | Ser698 | PEWPRRAsCTSSTSG | phosphorylation down-regulates activity | 196939 | SIGNOR-253009 |
| GSK3B | GYS1 | Ser645 | RPASVPPsPSLSRHS | phosphorylation down-regulates activity | 6772446 | SIGNOR-253006 |
| CSNK2A1 | GYS1 | Thr713 | SKRNSVDtATSSSLS | phosphorylation unknown | 2117608 | SIGNOR-250884 |
| GSK3B | GYS1 | Ser645 | RPASVPPsPSLSRHS | phosphorylation down-regulates activity | 11427888 | SIGNOR-251238 |
| GSK3B | GYS1 | Ser641 | YRYPRPAsVPPSPSL | phosphorylation down-regulates activity | 11427888 | SIGNOR-251239 |
| GSK3B | GYS1 | Ser641 | YRYPRPAsVPPSPSL | phosphorylation down-regulates activity | 14593110 | SIGNOR-235793 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | GYS1 PSer649 | phosphorylation down-regulates ⊣ | GYS1 | 6772446 | SIGNOR-253007 |
| GSK3B | phosphorylation up-regulates → | GYS1 PSer649 | phosphorylation down-regulates ⊣ | GYS1 | 11427888 | SIGNOR-251240 |
| CSNK2A1 | phosphorylation up-regulates → | GYS1 PSer649 | phosphorylation down-regulates ⊣ | GYS1 | 2117608 | SIGNOR-250880 |
| GSK3A | phosphorylation up-regulates → | GYS1 PSer641 | phosphorylation down-regulates ⊣ | GYS1 | 14593110 | SIGNOR-118927 |
| PRKACA | phosphorylation up-regulates → | GYS1 PSer8 | phosphorylation down-regulates ⊣ | GYS1 | 2117608 | SIGNOR-249988 |
| CSNK2A1 | phosphorylation up-regulates → | GYS1 PSer698 | phosphorylation down-regulates ⊣ | GYS1 | 2117608 | SIGNOR-250883 |
| CSNK2A1 | phosphorylation up-regulates → | GYS1 PSer645 | phosphorylation down-regulates ⊣ | GYS1 | 2117608 | SIGNOR-250879 |
| PRKACA | phosphorylation up-regulates → | GYS1 PSer8 | phosphorylation down-regulates ⊣ | GYS1 | 6263629 | SIGNOR-253008 |
| CSNK2A1 | phosphorylation up-regulates → | GYS1 PSer653 | phosphorylation down-regulates ⊣ | GYS1 | 2117608 | SIGNOR-250881 |
| AMPK | phosphorylation up-regulates → | GYS1 PSer8 | phosphorylation down-regulates ⊣ | GYS1 | 22233421 | SIGNOR-263102 |
| GSK3B | phosphorylation up-regulates → | GYS1 PSer653 | phosphorylation down-regulates ⊣ | GYS1 | 11427888 | SIGNOR-251241 |
| GSK3B | phosphorylation up-regulates → | GYS1 PSer641 | phosphorylation down-regulates ⊣ | GYS1 | 6772446 | SIGNOR-253005 |
| DYRK1A | phosphorylation up-regulates → | GYS1 PSer641 | phosphorylation down-regulates ⊣ | GYS1 | 14593110 | SIGNOR-260632 |
| CSNK2A1 | phosphorylation up-regulates → | GYS1 PSer10 | phosphorylation down-regulates ⊣ | GYS1 | 2117608 | SIGNOR-250878 |
| DYRK1B | phosphorylation up-regulates → | GYS1 PSer641 | phosphorylation down-regulates ⊣ | GYS1 | 14593110 | SIGNOR-260633 |
| PRKACA | phosphorylation up-regulates → | GYS1 PSer698 | phosphorylation down-regulates ⊣ | GYS1 | 196939 | SIGNOR-253009 |
| GSK3B | phosphorylation up-regulates → | GYS1 PSer645 | phosphorylation down-regulates ⊣ | GYS1 | 6772446 | SIGNOR-253006 |
| CSNK2A1 | phosphorylation up-regulates → | GYS1 PThr713 | phosphorylation down-regulates ⊣ | GYS1 | 2117608 | SIGNOR-250884 |
| GSK3B | phosphorylation up-regulates → | GYS1 PSer645 | phosphorylation down-regulates ⊣ | GYS1 | 11427888 | SIGNOR-251238 |
| GSK3B | phosphorylation up-regulates → | GYS1 PSer641 | phosphorylation down-regulates ⊣ | GYS1 | 11427888 | SIGNOR-251239 |
| GSK3B | phosphorylation up-regulates → | GYS1 PSer641 | phosphorylation down-regulates ⊣ | GYS1 | 14593110 | SIGNOR-235793 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation → down-regulates activity | GYS1 | SIGNOR-253007 |
| GSK3B | phosphorylation → down-regulates activity | GYS1 | SIGNOR-251240 |
| CSNK2A1 | phosphorylation → unknown | GYS1 | SIGNOR-250880 |
| GSK3A | phosphorylation down-regulates | GYS1 | SIGNOR-118927 |
| PRKACA | phosphorylation → unknown | GYS1 | SIGNOR-249988 |
| PPP1R3A | dephosphorylation → up-regulates | GYS1 | SIGNOR-37301 |
| CSNK2A1 | phosphorylation → unknown | GYS1 | SIGNOR-250883 |
| CSNK2A1 | phosphorylation → unknown | GYS1 | SIGNOR-250879 |
| PRKACA | phosphorylation → down-regulates activity | GYS1 | SIGNOR-253008 |
| PASK | phosphorylation → down-regulates activity | GYS1 | SIGNOR-245866 |
| CSNK2A1 | phosphorylation → unknown | GYS1 | SIGNOR-250881 |
| AMPK | phosphorylation → down-regulates activity | GYS1 | SIGNOR-263102 |
| GSK3B | phosphorylation → down-regulates activity | GYS1 | SIGNOR-251241 |
| GSK3B | phosphorylation → down-regulates activity | GYS1 | SIGNOR-253005 |
| DYRK1A | phosphorylation → down-regulates activity | GYS1 | SIGNOR-260632 |
| CSNK2A1 | phosphorylation → unknown | GYS1 | SIGNOR-250878 |
| DYRK1B | phosphorylation → down-regulates activity | GYS1 | SIGNOR-260633 |
| PRKACA | phosphorylation → down-regulates activity | GYS1 | SIGNOR-253009 |
| GSK3B | phosphorylation → down-regulates activity | GYS1 | SIGNOR-253006 |
| CSNK2A1 | phosphorylation → unknown | GYS1 | SIGNOR-250884 |
| GSK3B | phosphorylation → down-regulates activity | GYS1 | SIGNOR-251238 |
| GSK3B | phosphorylation → down-regulates activity | GYS1 | SIGNOR-251239 |
| GSK3B | phosphorylation → down-regulates activity | GYS1 | SIGNOR-235793 |
