| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | GYS1 | Ser645 | RPASVPPsPSLSRHS | phosphorylation unknown | 2117608 | SIGNOR-250879 |
| GSK3B | GYS1 | Ser645 | RPASVPPsPSLSRHS | phosphorylation down-regulates activity | 6772446 | SIGNOR-253006 |
| GSK3B | GYS1 | Ser645 | RPASVPPsPSLSRHS | phosphorylation down-regulates activity | 11427888 | SIGNOR-251238 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | phosphorylation up-regulates → | GYS1 PSer645 | phosphorylation down-regulates ⊣ | GYS1 | 2117608 | SIGNOR-250879 |
| GSK3B | phosphorylation up-regulates → | GYS1 PSer645 | phosphorylation down-regulates ⊣ | GYS1 | 6772446 | SIGNOR-253006 |
| GSK3B | phosphorylation up-regulates → | GYS1 PSer645 | phosphorylation down-regulates ⊣ | GYS1 | 11427888 | SIGNOR-251238 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A1 | phosphorylation → unknown | GYS1 | SIGNOR-250879 |
| GSK3B | phosphorylation → down-regulates activity | GYS1 | SIGNOR-253006 |
| GSK3B | phosphorylation → down-regulates activity | GYS1 | SIGNOR-251238 |