| Name | HCLS1 |
| ID | P14317 |
| Role | substrate |
| Enzymatic Domains |
SH3 428-486 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LYN | HCLS1 | Tyr397 | EDEPEGDyEEVLEPE | phosphorylation up-regulates activity | 9104825 | SIGNOR-251401 |
| LYN | HCLS1 | Tyr222 | MEAPTTAyKKTTPIE | phosphorylation unknown | 10066823 | SIGNOR-251399 |
| SYK | HCLS1 | Tyr397 | EDEPEGDyEEVLEPE | phosphorylation up-regulates | 9104825 | SIGNOR-47342 |
| CSNK2A1 | HCLS1 | Thr16 | DVSVSVEtQGDDWDT | phosphorylation unknown | 10806407 | SIGNOR-250885 |
| SYK | HCLS1 | Tyr378 | EPEPENDyEDVEEMD | phosphorylation up-regulates | 9104825 | SIGNOR-47338 |
| LYN | HCLS1 | Tyr378 | EPEPENDyEDVEEMD | phosphorylation up-regulates activity | 9104825 | SIGNOR-251400 |
| CSNK2A1 | HCLS1 | Thr23 | TQGDDWDtDPDFVND | phosphorylation unknown | 10806407 | SIGNOR-250886 |
| FGR | HCLS1 | Tyr222 | MEAPTTAyKKTTPIE | phosphorylation unknown | 10066823 | SIGNOR-251144 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LYN | phosphorylation up-regulates → | HCLS1 PTyr397 | phosphorylation up-regulates → | HCLS1 | 9104825 | SIGNOR-251401 |
| LYN | phosphorylation up-regulates → | HCLS1 PTyr222 | phosphorylation down-regulates ⊣ | HCLS1 | 10066823 | SIGNOR-251399 |
| SYK | phosphorylation up-regulates → | HCLS1 PTyr397 | phosphorylation up-regulates → | HCLS1 | 9104825 | SIGNOR-47342 |
| CSNK2A1 | phosphorylation up-regulates → | HCLS1 PThr16 | phosphorylation down-regulates ⊣ | HCLS1 | 10806407 | SIGNOR-250885 |
| SYK | phosphorylation up-regulates → | HCLS1 PTyr378 | phosphorylation up-regulates → | HCLS1 | 9104825 | SIGNOR-47338 |
| LYN | phosphorylation up-regulates → | HCLS1 PTyr378 | phosphorylation up-regulates → | HCLS1 | 9104825 | SIGNOR-251400 |
| CSNK2A1 | phosphorylation up-regulates → | HCLS1 PThr23 | phosphorylation down-regulates ⊣ | HCLS1 | 10806407 | SIGNOR-250886 |
| FGR | phosphorylation up-regulates → | HCLS1 PTyr222 | phosphorylation down-regulates ⊣ | HCLS1 | 10066823 | SIGNOR-251144 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LYN | phosphorylation → up-regulates activity | HCLS1 | SIGNOR-251401 |
| LYN | phosphorylation → unknown | HCLS1 | SIGNOR-251399 |
| SYK | phosphorylation → up-regulates | HCLS1 | SIGNOR-47342 |
| CSNK2A1 | phosphorylation → unknown | HCLS1 | SIGNOR-250885 |
| SYK | phosphorylation → up-regulates | HCLS1 | SIGNOR-47338 |
| LYN | phosphorylation → up-regulates activity | HCLS1 | SIGNOR-251400 |
| CSNK2A1 | phosphorylation → unknown | HCLS1 | SIGNOR-250886 |
| FGR | phosphorylation → unknown | HCLS1 | SIGNOR-251144 |