| Name | NCF1 |
| ID | P14598 |
| Role | substrate |
| Enzymatic Domains |
PX 4-125 PROSITE-ProRule
SH3 1 156-215 PROSITE-ProRule
SH3 2 226-285 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IRAK4 | NCF1 | Ser320 | QRSRKRLsQDAYRRN | phosphorylation up-regulates | 17217339 | SIGNOR-152015 |
| PRKCD | NCF1 | Ser315 | AHSIHQRsRKRLSQD | phosphorylation up-regulates | 12056906 | SIGNOR-89225 |
| IRAK4 | NCF1 | Ser345 | QARPGPQsPGSPLEE | phosphorylation up-regulates | 17217339 | SIGNOR-152019 |
| PRKCZ | NCF1 | Ser303 | RGAPPRRsSIRNAHS | phosphorylation up-regulates | 12056906 | SIGNOR-89252 |
| PRKCB | NCF1 | Ser379 | DLILNRCsESTKRKL | phosphorylation up-regulates | 12056906 | SIGNOR-89213 |
| IRAK4 | NCF1 | Ser288 | QKSGQDVsQAQRQIK | phosphorylation up-regulates | 17217339 | SIGNOR-152011 |
| PRKCA | NCF1 | Ser328 | QDAYRRNsVRFLQQR | phosphorylation up-regulates | 12056906 | SIGNOR-89166 |
| PRKCZ | NCF1 | Ser320 | QRSRKRLsQDAYRRN | phosphorylation up-regulates | 12056906 | SIGNOR-89268 |
| PRKCA | NCF1 | Ser379 | DLILNRCsESTKRKL | phosphorylation up-regulates | 12056906 | SIGNOR-89178 |
| AKT1 | NCF1 | Ser304 | GAPPRRSsIRNAHSI | phosphorylation up-regulates | 10559253 | SIGNOR-252586 |
| PRKCZ | NCF1 | Ser359 | EERQTQRsKPQPAVP | phosphorylation up-regulates | 12056906 | SIGNOR-89280 |
| PRKCB | NCF1 | Ser328 | QDAYRRNsVRFLQQR | phosphorylation up-regulates | 12056906 | SIGNOR-89201 |
| PRKCZ | NCF1 | Ser328 | QDAYRRNsVRFLQQR | phosphorylation up-regulates | 12056906 | SIGNOR-89272 |
| PRKCD | NCF1 | Ser359 | EERQTQRsKPQPAVP | phosphorylation up-regulates | 12056906 | SIGNOR-89237 |
| PRKCA | NCF1 | Ser370 | PAVPPRPsADLILNR | phosphorylation up-regulates | 12056906 | SIGNOR-89174 |
| MAPK1 | NCF1 | Ser345 | QARPGPQsPGSPLEE | phosphorylation up-regulates | 16778989 | SIGNOR-147170 |
| PRKCD | NCF1 | Ser303 | RGAPPRRsSIRNAHS | phosphorylation up-regulates | 12056906 | SIGNOR-89217 |
| PRKCA | NCF1 | Ser315 | AHSIHQRsRKRLSQD | phosphorylation up-regulates | 12056906 | SIGNOR-89158 |
| AKT | NCF1 | Ser328 | QDAYRRNsVRFLQQR | phosphorylation up-regulates | 10559253 | SIGNOR-72137 |
| MAPK3 | NCF1 | Ser345 | QARPGPQsPGSPLEE | phosphorylation up-regulates | 8626435 | SIGNOR-40821 |
| PRKCB | NCF1 | Ser370 | PAVPPRPsADLILNR | phosphorylation up-regulates | 12056906 | SIGNOR-89209 |
| PRKCD | NCF1 | Ser379 | DLILNRCsESTKRKL | phosphorylation up-regulates activity | 24632950 | SIGNOR-276622 |
| PRKCA | NCF1 | Ser359 | EERQTQRsKPQPAVP | phosphorylation up-regulates | 12056906 | SIGNOR-89170 |
| PRKCZ | NCF1 | Ser304 | GAPPRRSsIRNAHSI | phosphorylation up-regulates | 12056906 | SIGNOR-89260 |
| PRKCD | NCF1 | Ser320 | QRSRKRLsQDAYRRN | phosphorylation up-regulates | 12056906 | SIGNOR-89229 |
| PRKCD | NCF1 | Ser328 | QDAYRRNsVRFLQQR | phosphorylation up-regulates | 12056906 | SIGNOR-89233 |
| PRKCD | NCF1 | Ser348 | PGPQSPGsPLEEERQ | phosphorylation up-regulates activity | 24632950 | SIGNOR-276623 |
| PRKCD | NCF1 | Ser370 | PAVPPRPsADLILNR | phosphorylation up-regulates | 12056906 | SIGNOR-89241 |
| PRKCB | NCF1 | Ser359 | EERQTQRsKPQPAVP | phosphorylation up-regulates | 12056906 | SIGNOR-89205 |
| PRKCZ | NCF1 | Ser379 | DLILNRCsESTKRKL | phosphorylation up-regulates | 12056906 | SIGNOR-89288 |
| PRKCB | NCF1 | Ser320 | QRSRKRLsQDAYRRN | phosphorylation up-regulates | 12056906 | SIGNOR-89197 |
| PRKCB | NCF1 | Ser303 | RGAPPRRsSIRNAHS | phosphorylation up-regulates | 12056906 | SIGNOR-89182 |
| PRKCB | NCF1 | Ser304 | GAPPRRSsIRNAHSI | phosphorylation up-regulates | 12056906 | SIGNOR-89186 |
| ERK1/2 | NCF1 | – | phosphorylation up-regulates | 16778989 | SIGNOR-270187 | |
| AKT | NCF1 | Ser304 | GAPPRRSsIRNAHSI | phosphorylation up-regulates | 10559253 | SIGNOR-72133 |
| AKT1 | NCF1 | Ser328 | QDAYRRNsVRFLQQR | phosphorylation up-regulates | 10559253 | SIGNOR-252587 |
| MAPK3 | NCF1 | Ser345 | QARPGPQsPGSPLEE | phosphorylation up-regulates | 16778989 | SIGNOR-147174 |
| IRAK4 | NCF1 | Thr356 | PLEEERQtQRSKPQP | phosphorylation up-regulates | 17217339 | SIGNOR-152027 |
| PRKCZ | NCF1 | Ser370 | PAVPPRPsADLILNR | phosphorylation up-regulates | 12056906 | SIGNOR-89284 |
| PRKCA | NCF1 | Ser304 | GAPPRRSsIRNAHSI | phosphorylation up-regulates | 12056906 | SIGNOR-89154 |
| PRKCD | NCF1 | Ser304 | GAPPRRSsIRNAHSI | phosphorylation up-regulates | 12056906 | SIGNOR-89221 |
| PRKCD | NCF1 | Ser379 | DLILNRCsESTKRKL | phosphorylation up-regulates | 12056906 | SIGNOR-89248 |
| PRKCA | NCF1 | Ser303 | RGAPPRRsSIRNAHS | phosphorylation up-regulates | 12056906 | SIGNOR-89150 |
| IRAK4 | NCF1 | Thr133 | KLPTDNQtKKPETYL | phosphorylation up-regulates | 17217339 | SIGNOR-152023 |
| PRKCZ | NCF1 | Ser315 | AHSIHQRsRKRLSQD | phosphorylation up-regulates | 12056906 | SIGNOR-89264 |
| PRKCA | NCF1 | Ser320 | QRSRKRLsQDAYRRN | phosphorylation up-regulates | 12056906 | SIGNOR-89162 |
| Gbeta | NCF1 | – | phosphorylation up-regulates | 16778989 | SIGNOR-270091 | |
| PRKCB | NCF1 | Ser315 | AHSIHQRsRKRLSQD | phosphorylation up-regulates | 12056906 | SIGNOR-89193 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IRAK4 | phosphorylation up-regulates → | NCF1 PSer320 | phosphorylation up-regulates → | NCF1 | 17217339 | SIGNOR-152015 |
| PRKCD | phosphorylation up-regulates → | NCF1 PSer315 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89225 |
| IRAK4 | phosphorylation up-regulates → | NCF1 PSer345 | phosphorylation up-regulates → | NCF1 | 17217339 | SIGNOR-152019 |
| PRKCZ | phosphorylation up-regulates → | NCF1 PSer303 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89252 |
| PRKCB | phosphorylation up-regulates → | NCF1 PSer379 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89213 |
| IRAK4 | phosphorylation up-regulates → | NCF1 PSer288 | phosphorylation up-regulates → | NCF1 | 17217339 | SIGNOR-152011 |
| PRKCA | phosphorylation up-regulates → | NCF1 PSer328 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89166 |
| PRKCZ | phosphorylation up-regulates → | NCF1 PSer320 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89268 |
| PRKCA | phosphorylation up-regulates → | NCF1 PSer379 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89178 |
| AKT1 | phosphorylation up-regulates → | NCF1 PSer304 | phosphorylation up-regulates → | NCF1 | 10559253 | SIGNOR-252586 |
| PRKCZ | phosphorylation up-regulates → | NCF1 PSer359 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89280 |
| PRKCB | phosphorylation up-regulates → | NCF1 PSer328 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89201 |
| PRKCZ | phosphorylation up-regulates → | NCF1 PSer328 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89272 |
| PRKCD | phosphorylation up-regulates → | NCF1 PSer359 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89237 |
| PRKCA | phosphorylation up-regulates → | NCF1 PSer370 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89174 |
| MAPK1 | phosphorylation up-regulates → | NCF1 PSer345 | phosphorylation up-regulates → | NCF1 | 16778989 | SIGNOR-147170 |
| PRKCD | phosphorylation up-regulates → | NCF1 PSer303 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89217 |
| PRKCA | phosphorylation up-regulates → | NCF1 PSer315 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89158 |
| AKT | phosphorylation up-regulates → | NCF1 PSer328 | phosphorylation up-regulates → | NCF1 | 10559253 | SIGNOR-72137 |
| MAPK3 | phosphorylation up-regulates → | NCF1 PSer345 | phosphorylation up-regulates → | NCF1 | 8626435 | SIGNOR-40821 |
| PRKCB | phosphorylation up-regulates → | NCF1 PSer370 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89209 |
| PRKCD | phosphorylation up-regulates → | NCF1 PSer379 | phosphorylation up-regulates → | NCF1 | 24632950 | SIGNOR-276622 |
| PRKCA | phosphorylation up-regulates → | NCF1 PSer359 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89170 |
| PRKCZ | phosphorylation up-regulates → | NCF1 PSer304 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89260 |
| PRKCD | phosphorylation up-regulates → | NCF1 PSer320 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89229 |
| PRKCD | phosphorylation up-regulates → | NCF1 PSer328 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89233 |
| PRKCD | phosphorylation up-regulates → | NCF1 PSer348 | phosphorylation up-regulates → | NCF1 | 24632950 | SIGNOR-276623 |
| PRKCD | phosphorylation up-regulates → | NCF1 PSer370 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89241 |
| PRKCB | phosphorylation up-regulates → | NCF1 PSer359 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89205 |
| PRKCZ | phosphorylation up-regulates → | NCF1 PSer379 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89288 |
| PRKCB | phosphorylation up-regulates → | NCF1 PSer320 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89197 |
| PRKCB | phosphorylation up-regulates → | NCF1 PSer303 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89182 |
| PRKCB | phosphorylation up-regulates → | NCF1 PSer304 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89186 |
| AKT | phosphorylation up-regulates → | NCF1 PSer304 | phosphorylation up-regulates → | NCF1 | 10559253 | SIGNOR-72133 |
| AKT1 | phosphorylation up-regulates → | NCF1 PSer328 | phosphorylation up-regulates → | NCF1 | 10559253 | SIGNOR-252587 |
| MAPK3 | phosphorylation up-regulates → | NCF1 PSer345 | phosphorylation up-regulates → | NCF1 | 16778989 | SIGNOR-147174 |
| IRAK4 | phosphorylation up-regulates → | NCF1 PThr356 | phosphorylation up-regulates → | NCF1 | 17217339 | SIGNOR-152027 |
| PRKCZ | phosphorylation up-regulates → | NCF1 PSer370 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89284 |
| PRKCA | phosphorylation up-regulates → | NCF1 PSer304 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89154 |
| PRKCD | phosphorylation up-regulates → | NCF1 PSer304 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89221 |
| PRKCD | phosphorylation up-regulates → | NCF1 PSer379 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89248 |
| PRKCA | phosphorylation up-regulates → | NCF1 PSer303 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89150 |
| IRAK4 | phosphorylation up-regulates → | NCF1 PThr133 | phosphorylation up-regulates → | NCF1 | 17217339 | SIGNOR-152023 |
| PRKCZ | phosphorylation up-regulates → | NCF1 PSer315 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89264 |
| PRKCA | phosphorylation up-regulates → | NCF1 PSer320 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89162 |
| PRKCB | phosphorylation up-regulates → | NCF1 PSer315 | phosphorylation up-regulates → | NCF1 | 12056906 | SIGNOR-89193 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IRAK4 | phosphorylation → up-regulates | NCF1 | SIGNOR-152015 |
| PRKCD | phosphorylation → up-regulates | NCF1 | SIGNOR-89225 |
| IRAK4 | phosphorylation → up-regulates | NCF1 | SIGNOR-152019 |
| PRKCZ | phosphorylation → up-regulates | NCF1 | SIGNOR-89252 |
| PRKCB | phosphorylation → up-regulates | NCF1 | SIGNOR-89213 |
| IRAK4 | phosphorylation → up-regulates | NCF1 | SIGNOR-152011 |
| PRKCA | phosphorylation → up-regulates | NCF1 | SIGNOR-89166 |
| PRKCZ | phosphorylation → up-regulates | NCF1 | SIGNOR-89268 |
| PRKCA | phosphorylation → up-regulates | NCF1 | SIGNOR-89178 |
| AKT1 | phosphorylation → up-regulates | NCF1 | SIGNOR-252586 |
| PRKCZ | phosphorylation → up-regulates | NCF1 | SIGNOR-89280 |
| PRKCB | phosphorylation → up-regulates | NCF1 | SIGNOR-89201 |
| PRKCZ | phosphorylation → up-regulates | NCF1 | SIGNOR-89272 |
| PRKCD | phosphorylation → up-regulates | NCF1 | SIGNOR-89237 |
| PRKCA | phosphorylation → up-regulates | NCF1 | SIGNOR-89174 |
| MAPK1 | phosphorylation → up-regulates | NCF1 | SIGNOR-147170 |
| PRKCD | phosphorylation → up-regulates | NCF1 | SIGNOR-89217 |
| PRKCA | phosphorylation → up-regulates | NCF1 | SIGNOR-89158 |
| AKT | phosphorylation → up-regulates | NCF1 | SIGNOR-72137 |
| MAPK3 | phosphorylation → up-regulates | NCF1 | SIGNOR-40821 |
| PRKCB | phosphorylation → up-regulates | NCF1 | SIGNOR-89209 |
| PRKCD | phosphorylation → up-regulates activity | NCF1 | SIGNOR-276622 |
| PRKCA | phosphorylation → up-regulates | NCF1 | SIGNOR-89170 |
| PRKCZ | phosphorylation → up-regulates | NCF1 | SIGNOR-89260 |
| PRKCD | phosphorylation → up-regulates | NCF1 | SIGNOR-89229 |
| PRKCD | phosphorylation → up-regulates | NCF1 | SIGNOR-89233 |
| PRKCD | phosphorylation → up-regulates activity | NCF1 | SIGNOR-276623 |
| PRKCD | phosphorylation → up-regulates | NCF1 | SIGNOR-89241 |
| PRKCB | phosphorylation → up-regulates | NCF1 | SIGNOR-89205 |
| PRKCZ | phosphorylation → up-regulates | NCF1 | SIGNOR-89288 |
| PRKCB | phosphorylation → up-regulates | NCF1 | SIGNOR-89197 |
| PRKCB | phosphorylation → up-regulates | NCF1 | SIGNOR-89182 |
| PRKCB | phosphorylation → up-regulates | NCF1 | SIGNOR-89186 |
| ERK1/2 | phosphorylation → up-regulates | NCF1 | SIGNOR-270187 |
| AKT | phosphorylation → up-regulates | NCF1 | SIGNOR-72133 |
| AKT1 | phosphorylation → up-regulates | NCF1 | SIGNOR-252587 |
| MAPK3 | phosphorylation → up-regulates | NCF1 | SIGNOR-147174 |
| IRAK4 | phosphorylation → up-regulates | NCF1 | SIGNOR-152027 |
| PRKCZ | phosphorylation → up-regulates | NCF1 | SIGNOR-89284 |
| PRKCA | phosphorylation → up-regulates | NCF1 | SIGNOR-89154 |
| PRKCD | phosphorylation → up-regulates | NCF1 | SIGNOR-89221 |
| PRKCD | phosphorylation → up-regulates | NCF1 | SIGNOR-89248 |
| PRKCA | phosphorylation → up-regulates | NCF1 | SIGNOR-89150 |
| IRAK4 | phosphorylation → up-regulates | NCF1 | SIGNOR-152023 |
| PRKCZ | phosphorylation → up-regulates | NCF1 | SIGNOR-89264 |
| PRKCA | phosphorylation → up-regulates | NCF1 | SIGNOR-89162 |
| Gbeta | phosphorylation → up-regulates | NCF1 | SIGNOR-270091 |
| PRKCB | phosphorylation → up-regulates | NCF1 | SIGNOR-89193 |