| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | PKM | Tyr105 | FASDPILyRPVAVAL | dephosphorylation down-regulates activity | 26959741 | SIGNOR-276997 |
| PIM2 | PKM | Thr454 | RAPIIAVtRNPQTAR | phosphorylation up-regulates quantity by stabilization | 24142698 | SIGNOR-260905 |
| CDC25A | PKM | Ser37 | MCRLDIDsPPITARN | dephosphorylation up-regulates activity | 27485204 | SIGNOR-276967 |
| CyclinD3/CDK6 | PKM | Ser37 | MCRLDIDsPPITARN | phosphorylation down-regulates activity | 28607489 | SIGNOR-276453 |
| CyclinD3/CDK6 | PKM | Ser37 | MCRLDIDsPPITARN | phosphorylation down-regulates activity | 28607489 | SIGNOR-273032 |
| CDK6 | PKM | – | phosphorylation down-regulates activity | 28607489 | SIGNOR-279158 | |
| ACP1 | PKM | – | dephosphorylation up-regulates activity | 30251652 | SIGNOR-277134 | |
| EGFR | PKM | Tyr148 | KITLDNAyMEKCDEN | phosphorylation down-regulates activity | 26759242 | SIGNOR-277197 |
| MAPK8 | PKM | Thr365 | CIMLSGEtAKGDYPL | phosphorylation up-regulates activity | 26258887 | SIGNOR-276933 |
| PIM2 | PKM | Thr454 | RAPIIAVtRNPQTAR | phosphorylation up-regulates quantity by stabilization | 24142698 | SIGNOR-267472 |
| CyclinD3/CDK6 | PKM | Ser37 | MCRLDIDsPPITARN | phosphorylation down-regulates activity | 28607489 | SIGNOR-276454 |
| TRIB2 | PKM | Ser37 | MCRLDIDsPPITARN | phosphorylation up-regulates activity | 35790734 | SIGNOR-275431 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | dephosphorylation down-regulates ⊣ | PKM PTyr105 | dephosphorylation up-regulates → | PKM | 26959741 | SIGNOR-276997 |
| PIM2 | phosphorylation up-regulates → | PKM PThr454 | phosphorylation up-regulates → | PKM | 24142698 | SIGNOR-260905 |
| CDC25A | dephosphorylation down-regulates ⊣ | PKM PSer37 | dephosphorylation down-regulates ⊣ | PKM | 27485204 | SIGNOR-276967 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | PKM PSer37 | phosphorylation down-regulates ⊣ | PKM | 28607489 | SIGNOR-276453 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | PKM PSer37 | phosphorylation down-regulates ⊣ | PKM | 28607489 | SIGNOR-273032 |
| EGFR | phosphorylation up-regulates → | PKM PTyr148 | phosphorylation down-regulates ⊣ | PKM | 26759242 | SIGNOR-277197 |
| MAPK8 | phosphorylation up-regulates → | PKM PThr365 | phosphorylation up-regulates → | PKM | 26258887 | SIGNOR-276933 |
| PIM2 | phosphorylation up-regulates → | PKM PThr454 | phosphorylation up-regulates → | PKM | 24142698 | SIGNOR-267472 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | PKM PSer37 | phosphorylation down-regulates ⊣ | PKM | 28607489 | SIGNOR-276454 |
| TRIB2 | phosphorylation up-regulates → | PKM PSer37 | phosphorylation up-regulates → | PKM | 35790734 | SIGNOR-275431 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN6 | dephosphorylation → down-regulates activity | PKM | SIGNOR-276997 |
| PIM2 | phosphorylation → up-regulates quantity by stabilization | PKM | SIGNOR-260905 |
| CDC25A | dephosphorylation → up-regulates activity | PKM | SIGNOR-276967 |
| CyclinD3/CDK6 | phosphorylation → down-regulates activity | PKM | SIGNOR-276453 |
| CyclinD3/CDK6 | phosphorylation → down-regulates activity | PKM | SIGNOR-273032 |
| CDK6 | phosphorylation → down-regulates activity | PKM | SIGNOR-279158 |
| ACP1 | dephosphorylation → up-regulates activity | PKM | SIGNOR-277134 |
| EGFR | phosphorylation → down-regulates activity | PKM | SIGNOR-277197 |
| MAPK8 | phosphorylation → up-regulates activity | PKM | SIGNOR-276933 |
| PIM2 | phosphorylation → up-regulates quantity by stabilization | PKM | SIGNOR-267472 |
| CyclinD3/CDK6 | phosphorylation → down-regulates activity | PKM | SIGNOR-276454 |
| TRIB2 | phosphorylation → up-regulates activity | PKM | SIGNOR-275431 |
