| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | PKM | Tyr105 | FASDPILyRPVAVAL | dephosphorylation down-regulates activity | 26959741 | SIGNOR-276997 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | dephosphorylation down-regulates ⊣ | PKM PTyr105 | dephosphorylation up-regulates → | PKM | 26959741 | SIGNOR-276997 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN6 | dephosphorylation → down-regulates activity | PKM | SIGNOR-276997 |
