| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC25A | PKM | Ser37 | MCRLDIDsPPITARN | dephosphorylation up-regulates activity | 27485204 | SIGNOR-276967 |
| CyclinD3/CDK6 | PKM | Ser37 | MCRLDIDsPPITARN | phosphorylation down-regulates activity | 28607489 | SIGNOR-276453 |
| CyclinD3/CDK6 | PKM | Ser37 | MCRLDIDsPPITARN | phosphorylation down-regulates activity | 28607489 | SIGNOR-273032 |
| CyclinD3/CDK6 | PKM | Ser37 | MCRLDIDsPPITARN | phosphorylation down-regulates activity | 28607489 | SIGNOR-276454 |
| TRIB2 | PKM | Ser37 | MCRLDIDsPPITARN | phosphorylation up-regulates activity | 35790734 | SIGNOR-275431 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC25A | dephosphorylation down-regulates ⊣ | PKM PSer37 | dephosphorylation down-regulates ⊣ | PKM | 27485204 | SIGNOR-276967 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | PKM PSer37 | phosphorylation down-regulates ⊣ | PKM | 28607489 | SIGNOR-276453 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | PKM PSer37 | phosphorylation down-regulates ⊣ | PKM | 28607489 | SIGNOR-273032 |
| CyclinD3/CDK6 | phosphorylation up-regulates → | PKM PSer37 | phosphorylation down-regulates ⊣ | PKM | 28607489 | SIGNOR-276454 |
| TRIB2 | phosphorylation up-regulates → | PKM PSer37 | phosphorylation up-regulates → | PKM | 35790734 | SIGNOR-275431 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDC25A | dephosphorylation → up-regulates activity | PKM | SIGNOR-276967 |
| CyclinD3/CDK6 | phosphorylation → down-regulates activity | PKM | SIGNOR-276453 |
| CyclinD3/CDK6 | phosphorylation → down-regulates activity | PKM | SIGNOR-273032 |
| CyclinD3/CDK6 | phosphorylation → down-regulates activity | PKM | SIGNOR-276454 |
| TRIB2 | phosphorylation → up-regulates activity | PKM | SIGNOR-275431 |
