Entity Details

Name CCNB1
ID P14635
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PLK1CCNB1Ser126PILVDTAsPSPMETSphosphorylation
up-regulates activity		11242082SIGNOR-105707
CDC25ACCNB1–dephosphorylation
up-regulates activity		16682204SIGNOR-277137
PLK1CCNB1Ser147EDLCQAFsDVILAVNphosphorylation
up-regulates activity		11242082SIGNOR-105719
PLK1CCNB1Ser133SPSPMETsGCAPAEEphosphorylation
up-regulates activity		11242082SIGNOR-105715
AURKACCNB1–phosphorylation
up-regulates activity		30250494SIGNOR-280186
PLK1CCNB1Ser128LVDTASPsPMETSGCphosphorylation
up-regulates activity		11242082SIGNOR-105711
CDC25CCCNB1–dephosphorylation
up-regulates activity		25949173SIGNOR-277099
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PLK1phosphorylation
up-regulates
→
CCNB1
PSer126		phosphorylation
up-regulates
→		CCNB111242082SIGNOR-105707
PLK1phosphorylation
up-regulates
→
CCNB1
PSer147		phosphorylation
up-regulates
→		CCNB111242082SIGNOR-105719
PLK1phosphorylation
up-regulates
→
CCNB1
PSer133		phosphorylation
up-regulates
→		CCNB111242082SIGNOR-105715
PLK1phosphorylation
up-regulates
→
CCNB1
PSer128		phosphorylation
up-regulates
→		CCNB111242082SIGNOR-105711
Regulator Mechanism/Effect Target SIGNOR-ID
PLK1phosphorylation
→
up-regulates activity 		CCNB1SIGNOR-105707
CDC25Adephosphorylation
→
up-regulates activity 		CCNB1SIGNOR-277137
PLK1phosphorylation
→
up-regulates activity 		CCNB1SIGNOR-105719
PLK1phosphorylation
→
up-regulates activity 		CCNB1SIGNOR-105715
AURKAphosphorylation
→
up-regulates activity 		CCNB1SIGNOR-280186
PLK1phosphorylation
→
up-regulates activity 		CCNB1SIGNOR-105711
CDC25Cdephosphorylation
→
up-regulates activity 		CCNB1SIGNOR-277099