| Name | IL2RB |
| ID | P14784 |
| Role | substrate |
| Enzymatic Domains |
Fibronectin type-III 134-234 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | IL2RB | Tyr384 | ACQVYFTyDPYSEED | phosphorylation unknown | 10214954 | SIGNOR-251376 |
| LCK | IL2RB | Tyr418 | LSGEDDAyCTFPSRD | phosphorylation unknown | 10214954 | SIGNOR-251378 |
| LCK | IL2RB | Tyr381 | EIEACQVyFTYDPYS | phosphorylation unknown | 10214954 | SIGNOR-251375 |
| JAK1 | IL2RB | Tyr364 | SCFTNQGyFFFHLPD | phosphorylation up-regulates activity | 8700888 | SIGNOR-251342 |
| JAK1 | IL2RB | Tyr418 | LSGEDDAyCTFPSRD | phosphorylation up-regulates activity | 8700888 | SIGNOR-251340 |
| JAK1 | IL2RB | Tyr536 | LPLNTDAyLSLQELQ | phosphorylation up-regulates activity | 8700888 | SIGNOR-251341 |
| PTPN6 | IL2RB | – | dephosphorylation down-regulates | 9520455 | SIGNOR-55989 | |
| LCK | IL2RB | Tyr536 | LPLNTDAyLSLQELQ | phosphorylation unknown | 10214954 | SIGNOR-251379 |
| LCK | IL2RB | Tyr387 | VYFTYDPySEEDPDE | phosphorylation unknown | 10214954 | SIGNOR-251377 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | phosphorylation up-regulates → | IL2RB PTyr384 | phosphorylation down-regulates ⊣ | IL2RB | 10214954 | SIGNOR-251376 |
| LCK | phosphorylation up-regulates → | IL2RB PTyr418 | phosphorylation down-regulates ⊣ | IL2RB | 10214954 | SIGNOR-251378 |
| LCK | phosphorylation up-regulates → | IL2RB PTyr381 | phosphorylation down-regulates ⊣ | IL2RB | 10214954 | SIGNOR-251375 |
| JAK1 | phosphorylation up-regulates → | IL2RB PTyr364 | phosphorylation up-regulates → | IL2RB | 8700888 | SIGNOR-251342 |
| JAK1 | phosphorylation up-regulates → | IL2RB PTyr418 | phosphorylation up-regulates → | IL2RB | 8700888 | SIGNOR-251340 |
| JAK1 | phosphorylation up-regulates → | IL2RB PTyr536 | phosphorylation up-regulates → | IL2RB | 8700888 | SIGNOR-251341 |
| LCK | phosphorylation up-regulates → | IL2RB PTyr536 | phosphorylation down-regulates ⊣ | IL2RB | 10214954 | SIGNOR-251379 |
| LCK | phosphorylation up-regulates → | IL2RB PTyr387 | phosphorylation down-regulates ⊣ | IL2RB | 10214954 | SIGNOR-251377 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LCK | phosphorylation → unknown | IL2RB | SIGNOR-251376 |
| LCK | phosphorylation → unknown | IL2RB | SIGNOR-251378 |
| LCK | phosphorylation → unknown | IL2RB | SIGNOR-251375 |
| JAK1 | phosphorylation → up-regulates activity | IL2RB | SIGNOR-251342 |
| JAK1 | phosphorylation → up-regulates activity | IL2RB | SIGNOR-251340 |
| JAK1 | phosphorylation → up-regulates activity | IL2RB | SIGNOR-251341 |
| PTPN6 | dephosphorylation down-regulates | IL2RB | SIGNOR-55989 |
| LCK | phosphorylation → unknown | IL2RB | SIGNOR-251379 |
| LCK | phosphorylation → unknown | IL2RB | SIGNOR-251377 |