| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | IL2RB | Tyr418 | LSGEDDAyCTFPSRD | phosphorylation unknown | 10214954 | SIGNOR-251378 |
| JAK1 | IL2RB | Tyr418 | LSGEDDAyCTFPSRD | phosphorylation up-regulates activity | 8700888 | SIGNOR-251340 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | phosphorylation up-regulates → | IL2RB PTyr418 | phosphorylation down-regulates ⊣ | IL2RB | 10214954 | SIGNOR-251378 |
| JAK1 | phosphorylation up-regulates → | IL2RB PTyr418 | phosphorylation up-regulates → | IL2RB | 8700888 | SIGNOR-251340 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LCK | phosphorylation → unknown | IL2RB | SIGNOR-251378 |
| JAK1 | phosphorylation → up-regulates activity | IL2RB | SIGNOR-251340 |
