| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK1 | IL2RB | Tyr536 | LPLNTDAyLSLQELQ | phosphorylation up-regulates activity | 8700888 | SIGNOR-251341 |
| LCK | IL2RB | Tyr536 | LPLNTDAyLSLQELQ | phosphorylation unknown | 10214954 | SIGNOR-251379 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK1 | phosphorylation up-regulates → | IL2RB PTyr536 | phosphorylation up-regulates → | IL2RB | 8700888 | SIGNOR-251341 |
| LCK | phosphorylation up-regulates → | IL2RB PTyr536 | phosphorylation down-regulates ⊣ | IL2RB | 10214954 | SIGNOR-251379 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JAK1 | phosphorylation → up-regulates activity | IL2RB | SIGNOR-251341 |
| LCK | phosphorylation → unknown | IL2RB | SIGNOR-251379 |
