| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK12 | MYOD1 | Ser200 | YSGDSDAsSPRSNCS | phosphorylation up-regulates activity | 20026657 | SIGNOR-276274 |
| CyclinB/CDK1 | MYOD1 | Ser200 | YSGDSDAsSPRSNCS | phosphorylation down-regulates | 14749395 | SIGNOR-216920 |
| CDK1 | MYOD1 | Ser200 | YSGDSDAsSPRSNCS | phosphorylation down-regulates | 14749395 | SIGNOR-121601 |
| CyclinE/CDK2 | MYOD1 | Ser200 | YSGDSDAsSPRSNCS | phosphorylation down-regulates | 21902831 | SIGNOR-216706 |
| CDK2 | MYOD1 | Ser200 | YSGDSDAsSPRSNCS | phosphorylation down-regulates | 21902831 | SIGNOR-176509 |
| CDK1 | MYOD1 | Ser200 | YSGDSDAsSPRSNCS | phosphorylation down-regulates | 21902831 | SIGNOR-176505 |
| CyclinB/CDK1 | MYOD1 | Ser200 | YSGDSDAsSPRSNCS | phosphorylation down-regulates | 21902831 | SIGNOR-216860 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK12 | phosphorylation up-regulates → | MYOD1 PSer200 | phosphorylation up-regulates → | MYOD1 | 20026657 | SIGNOR-276274 |
| CyclinB/CDK1 | phosphorylation up-regulates → | MYOD1 PSer200 | phosphorylation down-regulates ⊣ | MYOD1 | 14749395 | SIGNOR-216920 |
| CDK1 | phosphorylation up-regulates → | MYOD1 PSer200 | phosphorylation down-regulates ⊣ | MYOD1 | 14749395 | SIGNOR-121601 |
| CyclinE/CDK2 | phosphorylation up-regulates → | MYOD1 PSer200 | phosphorylation down-regulates ⊣ | MYOD1 | 21902831 | SIGNOR-216706 |
| CDK2 | phosphorylation up-regulates → | MYOD1 PSer200 | phosphorylation down-regulates ⊣ | MYOD1 | 21902831 | SIGNOR-176509 |
| CDK1 | phosphorylation up-regulates → | MYOD1 PSer200 | phosphorylation down-regulates ⊣ | MYOD1 | 21902831 | SIGNOR-176505 |
| CyclinB/CDK1 | phosphorylation up-regulates → | MYOD1 PSer200 | phosphorylation down-regulates ⊣ | MYOD1 | 21902831 | SIGNOR-216860 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK12 | phosphorylation → up-regulates activity | MYOD1 | SIGNOR-276274 |
| CyclinB/CDK1 | phosphorylation down-regulates | MYOD1 | SIGNOR-216920 |
| CDK1 | phosphorylation down-regulates | MYOD1 | SIGNOR-121601 |
| CyclinE/CDK2 | phosphorylation down-regulates | MYOD1 | SIGNOR-216706 |
| CDK2 | phosphorylation down-regulates | MYOD1 | SIGNOR-176509 |
| CDK1 | phosphorylation down-regulates | MYOD1 | SIGNOR-176505 |
| CyclinB/CDK1 | phosphorylation down-regulates | MYOD1 | SIGNOR-216860 |
