| Name | VAV1 |
| ID | P15498 |
| Role | substrate |
| Enzymatic Domains |
Calponin-homology (CH) 1-119 PROSITE-ProRule
DH 194-373 PROSITE-ProRule
PH 402-504 PROSITE-ProRule
SH3 1 592-660 PROSITE-ProRule
SH2 671-765 PROSITE-ProRule
SH3 2 782-842 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | VAV1 | – | phosphorylation up-regulates | 11790798 | SIGNOR-114091 | |
| BCR-ABL | VAV1 | – | phosphorylation up-regulates | 11790798 | SIGNOR-114094 | |
| PTPN6 | VAV1 | – | dephosphorylation down-regulates activity | 30567306 | SIGNOR-277171 | |
| SRC | VAV1 | – | phosphorylation up-regulates activity | 28930674 | SIGNOR-279124 | |
| FYN | VAV1 | – | phosphorylation up-regulates | 11005864 | SIGNOR-82287 | |
| ZAP70 | VAV1 | – | phosphorylation up-regulates activity | 23620790 | SIGNOR-278390 | |
| LCK | VAV1 | Tyr142 | SVGDEDIySGLSDQI | phosphorylation unknown | 10669745 | SIGNOR-251389 |
| LCK | VAV1 | Tyr174 | EAEGDEIyEDLMRSE | phosphorylation unknown | 10669745 | SIGNOR-251391 |
| LCK | VAV1 | Tyr160 | VEEDEDLyDCVENEE | phosphorylation unknown | 10669745 | SIGNOR-251390 |
| SYK | VAV1 | – | phosphorylation up-regulates | 11331248 | SIGNOR-107046 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | phosphorylation up-regulates → | VAV1 PTyr142 | phosphorylation down-regulates ⊣ | VAV1 | 10669745 | SIGNOR-251389 |
| LCK | phosphorylation up-regulates → | VAV1 PTyr174 | phosphorylation down-regulates ⊣ | VAV1 | 10669745 | SIGNOR-251391 |
| LCK | phosphorylation up-regulates → | VAV1 PTyr160 | phosphorylation down-regulates ⊣ | VAV1 | 10669745 | SIGNOR-251390 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ABL1 | phosphorylation → up-regulates | VAV1 | SIGNOR-114091 |
| BCR-ABL | phosphorylation → up-regulates | VAV1 | SIGNOR-114094 |
| PTPN6 | dephosphorylation → down-regulates activity | VAV1 | SIGNOR-277171 |
| SRC | phosphorylation → up-regulates activity | VAV1 | SIGNOR-279124 |
| FYN | phosphorylation → up-regulates | VAV1 | SIGNOR-82287 |
| ZAP70 | phosphorylation → up-regulates activity | VAV1 | SIGNOR-278390 |
| LCK | phosphorylation → unknown | VAV1 | SIGNOR-251389 |
| LCK | phosphorylation → unknown | VAV1 | SIGNOR-251391 |
| LCK | phosphorylation → unknown | VAV1 | SIGNOR-251390 |
| SYK | phosphorylation → up-regulates | VAV1 | SIGNOR-107046 |