| Name | MUC1 |
| ID | P15941 |
| Role | substrate |
| Enzymatic Domains |
SEA 1039-1148 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | MUC1 | Ser1227 | PPSSTDRsPYEKVSA | phosphorylation down-regulates activity | 9819408 | SIGNOR-249356 |
| SRC | MUC1 | Tyr1229 | SSTDRSPyEKVSAGN | phosphorylation up-regulates | 11152665 | SIGNOR-85938 |
| ZAP70 | MUC1 | Tyr1203 | IFPARDTyHPMSEYP | phosphorylation up-regulates activity | 14766232 | SIGNOR-247039 |
| LCK | MUC1 | Tyr1229 | SSTDRSPyEKVSAGN | phosphorylation up-regulates activity | 14766232 | SIGNOR-249358 |
| EGFR | MUC1 | Tyr1229 | SSTDRSPyEKVSAGN | phosphorylation up-regulates activity | 11483589 | SIGNOR-109538 |
| PRKCD | MUC1 | Thr1224 | RYVPPSStDRSPYEK | phosphorylation up-regulates | 11877440 | SIGNOR-115501 |
| ABL1 | MUC1 | Tyr1243 | NGGSSLSyTNPAVAA | phosphorylation up-regulates quantity by stabilization | 16888623 | SIGNOR-260830 |
| LCK | MUC1 | Tyr1229 | SSTDRSPyEKVSAGN | phosphorylation up-regulates activity | 14766232 | SIGNOR-247058 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | MUC1 PSer1227 | phosphorylation down-regulates ⊣ | MUC1 | 9819408 | SIGNOR-249356 |
| SRC | phosphorylation up-regulates → | MUC1 PTyr1229 | phosphorylation up-regulates → | MUC1 | 11152665 | SIGNOR-85938 |
| ZAP70 | phosphorylation up-regulates → | MUC1 PTyr1203 | phosphorylation up-regulates → | MUC1 | 14766232 | SIGNOR-247039 |
| LCK | phosphorylation up-regulates → | MUC1 PTyr1229 | phosphorylation up-regulates → | MUC1 | 14766232 | SIGNOR-249358 |
| EGFR | phosphorylation up-regulates → | MUC1 PTyr1229 | phosphorylation up-regulates → | MUC1 | 11483589 | SIGNOR-109538 |
| PRKCD | phosphorylation up-regulates → | MUC1 PThr1224 | phosphorylation up-regulates → | MUC1 | 11877440 | SIGNOR-115501 |
| ABL1 | phosphorylation up-regulates → | MUC1 PTyr1243 | phosphorylation up-regulates → | MUC1 | 16888623 | SIGNOR-260830 |
| LCK | phosphorylation up-regulates → | MUC1 PTyr1229 | phosphorylation up-regulates → | MUC1 | 14766232 | SIGNOR-247058 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation → down-regulates activity | MUC1 | SIGNOR-249356 |
| SRC | phosphorylation → up-regulates | MUC1 | SIGNOR-85938 |
| ZAP70 | phosphorylation → up-regulates activity | MUC1 | SIGNOR-247039 |
| LCK | phosphorylation → up-regulates activity | MUC1 | SIGNOR-249358 |
| EGFR | phosphorylation → up-regulates activity | MUC1 | SIGNOR-109538 |
| PRKCD | phosphorylation → up-regulates | MUC1 | SIGNOR-115501 |
| ABL1 | phosphorylation → up-regulates quantity by stabilization | MUC1 | SIGNOR-260830 |
| LCK | phosphorylation → up-regulates activity | MUC1 | SIGNOR-247058 |