| Name | ITGB4 |
| ID | P16144 |
| Role | substrate |
| Enzymatic Domains |
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VWFA 131-329 UniProtKB
I-EGF 1 457-491 PROSITE-ProRule
I-EGF 2 492-537 PROSITE-ProRule
I-EGF 3 538-574 PROSITE-ProRule
I-EGF 4 575-615 PROSITE-ProRule
Calx-beta 979-1084
Fibronectin type-III 1 1129-1218 PROSITE-ProRule
Fibronectin type-III 2 1222-1321 PROSITE-ProRule
Fibronectin type-III 3 1530-1625 PROSITE-ProRule
Fibronectin type-III 4 1643-1739 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | ITGB4 | Ser1360 | VLRSPSGsQRPSVSD | phosphorylation down-regulates | 15121854 | SIGNOR-124494 |
| RTKs | ITGB4 | – | phosphorylation up-regulates activity | 30889378 | SIGNOR-259031 | |
| PRKACA | ITGB4 | Ser1364 | PSGSQRPsVSDDTGC | phosphorylation down-regulates | 17615294 | SIGNOR-156873 |
| PRKCA | ITGB4 | Ser1494 | TLTRDYNsLTRSEHS | phosphorylation down-regulates | 15121854 | SIGNOR-124498 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | ITGB4 PSer1360 | phosphorylation down-regulates ⊣ | ITGB4 | 15121854 | SIGNOR-124494 |
| PRKACA | phosphorylation up-regulates → | ITGB4 PSer1364 | phosphorylation down-regulates ⊣ | ITGB4 | 17615294 | SIGNOR-156873 |
| PRKCA | phosphorylation up-regulates → | ITGB4 PSer1494 | phosphorylation down-regulates ⊣ | ITGB4 | 15121854 | SIGNOR-124498 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation down-regulates | ITGB4 | SIGNOR-124494 |
| RTKs | phosphorylation → up-regulates activity | ITGB4 | SIGNOR-259031 |
| PRKACA | phosphorylation down-regulates | ITGB4 | SIGNOR-156873 |
| PRKCA | phosphorylation down-regulates | ITGB4 | SIGNOR-124498 |