| Name | PECAM1 |
| ID | P16284 |
| Role | substrate |
| Enzymatic Domains |
Ig-like C2-type 1 35-121
Ig-like C2-type 2 145-233
Ig-like C2-type 3 236-315
Ig-like C2-type 4 328-401
Ig-like C2-type 5 424-493
Ig-like C2-type 6 499-591 |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | PECAM1 | Tyr713 | KKDTETVySEVRKAV | phosphorylation up-regulates activity | 9624175 | SIGNOR-262742 |
| FER | PECAM1 | Tyr690 | PLNSDVQyTEVQVSS | phosphorylation up-regulates activity | 12972546 | SIGNOR-262865 |
| CSK | PECAM1 | Tyr713 | KKDTETVySEVRKAV | phosphorylation up-regulates activity | 9624175 | SIGNOR-262741 |
| FES | PECAM1 | Tyr690 | PLNSDVQyTEVQVSS | phosphorylation up-regulates activity | 12972546 | SIGNOR-262867 |
| FER | PECAM1 | Tyr713 | KKDTETVySEVRKAV | phosphorylation up-regulates activity | 12972546 | SIGNOR-262866 |
| FES | PECAM1 | Tyr713 | KKDTETVySEVRKAV | phosphorylation up-regulates activity | 12972546 | SIGNOR-262868 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | phosphorylation up-regulates → | PECAM1 PTyr713 | phosphorylation up-regulates → | PECAM1 | 9624175 | SIGNOR-262742 |
| FER | phosphorylation up-regulates → | PECAM1 PTyr690 | phosphorylation up-regulates → | PECAM1 | 12972546 | SIGNOR-262865 |
| CSK | phosphorylation up-regulates → | PECAM1 PTyr713 | phosphorylation up-regulates → | PECAM1 | 9624175 | SIGNOR-262741 |
| FES | phosphorylation up-regulates → | PECAM1 PTyr690 | phosphorylation up-regulates → | PECAM1 | 12972546 | SIGNOR-262867 |
| FER | phosphorylation up-regulates → | PECAM1 PTyr713 | phosphorylation up-regulates → | PECAM1 | 12972546 | SIGNOR-262866 |
| FES | phosphorylation up-regulates → | PECAM1 PTyr713 | phosphorylation up-regulates → | PECAM1 | 12972546 | SIGNOR-262868 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LCK | phosphorylation → up-regulates activity | PECAM1 | SIGNOR-262742 |
| FER | phosphorylation → up-regulates activity | PECAM1 | SIGNOR-262865 |
| CSK | phosphorylation → up-regulates activity | PECAM1 | SIGNOR-262741 |
| FES | phosphorylation → up-regulates activity | PECAM1 | SIGNOR-262867 |
| FER | phosphorylation → up-regulates activity | PECAM1 | SIGNOR-262866 |
| FES | phosphorylation → up-regulates activity | PECAM1 | SIGNOR-262868 |