| Name | FER |
| ID | P16591 |
| Role | kinase |
| Enzymatic Domains |
F-BAR 1-259 PROSITE-ProRule
SH2 460-550 PROSITE-ProRule
Protein kinase 563-816 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FER | AR | Tyr225 | PTSSKDNyLGGTSTI | phosphorylation up-regulates | 23906537 | SIGNOR-194749 |
| FER | JUP | Tyr550 | AAGTQQPyTDGVRME | phosphorylation down-regulates activity | 14517306 | SIGNOR-251135 |
| FER | JUP | Tyr550 | AAGTQQPyTDGVRME | phosphorylation up-regulates activity | 14517306 | SIGNOR-251134 |
| FER | PECAM1 | Tyr690 | PLNSDVQyTEVQVSS | phosphorylation up-regulates activity | 12972546 | SIGNOR-262865 |
| FER | PECAM1 | Tyr713 | KKDTETVySEVRKAV | phosphorylation up-regulates activity | 12972546 | SIGNOR-262866 |
| FER | FER | Tyr714 | RQEDGGVySSSGLKQ | phosphorylation up-regulates activity | 10998246 | SIGNOR-251133 |
| FER | FER | Tyr714 | RQEDGGVySSSGLKQ | phosphorylation up-regulates activity | 19159681 | SIGNOR-276236 |
| FER | CTNNB1 | Tyr142 | AVVNLINyQDDAELA | phosphorylation down-regulates activity | 12640114 | SIGNOR-251131 |
| FER | STAT3 | – | phosphorylation up-regulates activity | 10878010 | SIGNOR-279713 | |
| FER | ARHGDIA | – | phosphorylation down-regulates activity | 21122136 | SIGNOR-279042 | |
| FER | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates activity | 19339212 | SIGNOR-279409 |
| FER | PRKCD | Tyr374 | ELKGRGEyFAIKALK | phosphorylation up-regulates activity | 33411917 | SIGNOR-277546 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FER | phosphorylation up-regulates → | AR PTyr225 | phosphorylation up-regulates → | AR | 23906537 | SIGNOR-194749 |
| FER | phosphorylation up-regulates → | JUP PTyr550 | phosphorylation down-regulates ⊣ | JUP | 14517306 | SIGNOR-251135 |
| FER | phosphorylation up-regulates → | JUP PTyr550 | phosphorylation up-regulates → | JUP | 14517306 | SIGNOR-251134 |
| FER | phosphorylation up-regulates → | PECAM1 PTyr690 | phosphorylation up-regulates → | PECAM1 | 12972546 | SIGNOR-262865 |
| FER | phosphorylation up-regulates → | PECAM1 PTyr713 | phosphorylation up-regulates → | PECAM1 | 12972546 | SIGNOR-262866 |
| FER | phosphorylation up-regulates → | FER PTyr714 | phosphorylation up-regulates → | FER | 10998246 | SIGNOR-251133 |
| FER | phosphorylation up-regulates → | FER PTyr714 | phosphorylation up-regulates → | FER | 19159681 | SIGNOR-276236 |
| FER | phosphorylation up-regulates → | CTNNB1 PTyr142 | phosphorylation down-regulates ⊣ | CTNNB1 | 12640114 | SIGNOR-251131 |
| FER | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 19339212 | SIGNOR-279409 |
| FER | phosphorylation up-regulates → | PRKCD PTyr374 | phosphorylation up-regulates → | PRKCD | 33411917 | SIGNOR-277546 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FER | phosphorylation → up-regulates | AR | SIGNOR-194749 |
| FER | phosphorylation → down-regulates activity | JUP | SIGNOR-251135 |
| FER | phosphorylation → up-regulates activity | JUP | SIGNOR-251134 |
| FER | phosphorylation → up-regulates activity | PECAM1 | SIGNOR-262865 |
| FER | phosphorylation → up-regulates activity | PECAM1 | SIGNOR-262866 |
| FER | phosphorylation → up-regulates activity | FER | SIGNOR-251133 |
| FER | phosphorylation → up-regulates activity | FER | SIGNOR-276236 |
| FER | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-251131 |
| FER | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279713 |
| FER | phosphorylation → down-regulates activity | ARHGDIA | SIGNOR-279042 |
| FER | phosphorylation → up-regulates activity | PTK2 | SIGNOR-279409 |
| FER | phosphorylation → up-regulates activity | PRKCD | SIGNOR-277546 |