| Name | PLCG2 |
| ID | P16885 |
| Role | substrate |
| Enzymatic Domains |
PH 20-131 PROSITE-ProRule
PI-PLC X-box 312-456 PROSITE-ProRule
SH2 1 532-635 PROSITE-ProRule
SH2 2 646-735 PROSITE-ProRule
SH3 769-829 PROSITE-ProRule
PI-PLC Y-box 930-1044 PROSITE-ProRule
C2 1038-1169 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BTK | PLCG2 | Tyr759 | LYDVSRMyVDPSEIN | phosphorylation up-regulates activity | 11507089 | SIGNOR-109758 |
| FYN | PLCG2 | Tyr759 | LYDVSRMyVDPSEIN | phosphorylation up-regulates activity | 7682059 | SIGNOR-249340 |
| LYN | PLCG2 | Tyr753 | ERDINSLyDVSRMYV | phosphorylation up-regulates activity | 7682059 | SIGNOR-249383 |
| LCK | PLCG2 | Tyr759 | LYDVSRMyVDPSEIN | phosphorylation up-regulates | 12181444 | SIGNOR-91477 |
| INPP5D | PLCG2 | – | dephosphorylation down-regulates activity | 32323266 | SIGNOR-268455 | |
| BTK | PLCG2 | Tyr759 | LYDVSRMyVDPSEIN | phosphorylation up-regulates | 11606584 | SIGNOR-111073 |
| TRPM7 | PLCG2 | Thr1045 | LQPESMRtEKYDPMP | phosphorylation up-regulates activity | 22759789 | SIGNOR-278459 |
| BLK | PLCG2 | – | phosphorylation up-regulates activity | 29545808 | SIGNOR-280195 | |
| SYK | PLCG2 | – | phosphorylation up-regulates activity | 25955968 | SIGNOR-278995 | |
| HCK | PLCG2 | Tyr753 | ERDINSLyDVSRMYV | phosphorylation up-regulates activity | 7682059 | SIGNOR-249363 |
| LYN | PLCG2 | Tyr759 | LYDVSRMyVDPSEIN | phosphorylation up-regulates activity | 7682059 | SIGNOR-249384 |
| BTK | PLCG2 | Tyr1217 | LNNQLFLyDTHQNLR | phosphorylation up-regulates activity | 11507089 | SIGNOR-109750 |
| BTK | PLCG2 | Tyr753 | ERDINSLyDVSRMYV | phosphorylation up-regulates activity | 11507089 | SIGNOR-109754 |
| BTK | PLCG2 | Tyr753 | ERDINSLyDVSRMYV | phosphorylation up-regulates | 11606584 | SIGNOR-111069 |
| LCK | PLCG2 | Tyr753 | ERDINSLyDVSRMYV | phosphorylation up-regulates | 12181444 | SIGNOR-91473 |
| BTK | PLCG2 | Tyr1197 | LESEEELySSCRQLR | phosphorylation up-regulates activity | 11507089 | SIGNOR-109746 |
| FYN | PLCG2 | Tyr753 | ERDINSLyDVSRMYV | phosphorylation up-regulates activity | 7682059 | SIGNOR-249339 |
| TRPM7 | PLCG2 | Ser1164 | AVKSGFRsVPLKNGY | phosphorylation up-regulates activity | 22759789 | SIGNOR-278460 |
| HCK | PLCG2 | Tyr759 | LYDVSRMyVDPSEIN | phosphorylation up-regulates activity | 7682059 | SIGNOR-249364 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BTK | phosphorylation up-regulates → | PLCG2 PTyr759 | phosphorylation up-regulates → | PLCG2 | 11507089 | SIGNOR-109758 |
| FYN | phosphorylation up-regulates → | PLCG2 PTyr759 | phosphorylation up-regulates → | PLCG2 | 7682059 | SIGNOR-249340 |
| LYN | phosphorylation up-regulates → | PLCG2 PTyr753 | phosphorylation up-regulates → | PLCG2 | 7682059 | SIGNOR-249383 |
| LCK | phosphorylation up-regulates → | PLCG2 PTyr759 | phosphorylation up-regulates → | PLCG2 | 12181444 | SIGNOR-91477 |
| BTK | phosphorylation up-regulates → | PLCG2 PTyr759 | phosphorylation up-regulates → | PLCG2 | 11606584 | SIGNOR-111073 |
| TRPM7 | phosphorylation up-regulates → | PLCG2 PThr1045 | phosphorylation up-regulates → | PLCG2 | 22759789 | SIGNOR-278459 |
| HCK | phosphorylation up-regulates → | PLCG2 PTyr753 | phosphorylation up-regulates → | PLCG2 | 7682059 | SIGNOR-249363 |
| LYN | phosphorylation up-regulates → | PLCG2 PTyr759 | phosphorylation up-regulates → | PLCG2 | 7682059 | SIGNOR-249384 |
| BTK | phosphorylation up-regulates → | PLCG2 PTyr1217 | phosphorylation up-regulates → | PLCG2 | 11507089 | SIGNOR-109750 |
| BTK | phosphorylation up-regulates → | PLCG2 PTyr753 | phosphorylation up-regulates → | PLCG2 | 11507089 | SIGNOR-109754 |
| BTK | phosphorylation up-regulates → | PLCG2 PTyr753 | phosphorylation up-regulates → | PLCG2 | 11606584 | SIGNOR-111069 |
| LCK | phosphorylation up-regulates → | PLCG2 PTyr753 | phosphorylation up-regulates → | PLCG2 | 12181444 | SIGNOR-91473 |
| BTK | phosphorylation up-regulates → | PLCG2 PTyr1197 | phosphorylation up-regulates → | PLCG2 | 11507089 | SIGNOR-109746 |
| FYN | phosphorylation up-regulates → | PLCG2 PTyr753 | phosphorylation up-regulates → | PLCG2 | 7682059 | SIGNOR-249339 |
| TRPM7 | phosphorylation up-regulates → | PLCG2 PSer1164 | phosphorylation up-regulates → | PLCG2 | 22759789 | SIGNOR-278460 |
| HCK | phosphorylation up-regulates → | PLCG2 PTyr759 | phosphorylation up-regulates → | PLCG2 | 7682059 | SIGNOR-249364 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| BTK | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-109758 |
| FYN | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-249340 |
| LYN | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-249383 |
| LCK | phosphorylation → up-regulates | PLCG2 | SIGNOR-91477 |
| INPP5D | dephosphorylation → down-regulates activity | PLCG2 | SIGNOR-268455 |
| BTK | phosphorylation → up-regulates | PLCG2 | SIGNOR-111073 |
| TRPM7 | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-278459 |
| BLK | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-280195 |
| SYK | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-278995 |
| HCK | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-249363 |
| LYN | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-249384 |
| BTK | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-109750 |
| BTK | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-109754 |
| BTK | phosphorylation → up-regulates | PLCG2 | SIGNOR-111069 |
| LCK | phosphorylation → up-regulates | PLCG2 | SIGNOR-91473 |
| BTK | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-109746 |
| FYN | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-249339 |
| TRPM7 | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-278460 |
| HCK | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-249364 |