| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BTK | PLCG2 | Tyr753 | ERDINSLyDVSRMYV | phosphorylation up-regulates activity | 11507089 | SIGNOR-109754 |
| BTK | PLCG2 | Tyr753 | ERDINSLyDVSRMYV | phosphorylation up-regulates | 11606584 | SIGNOR-111069 |
| LCK | PLCG2 | Tyr753 | ERDINSLyDVSRMYV | phosphorylation up-regulates | 12181444 | SIGNOR-91473 |
| FYN | PLCG2 | Tyr753 | ERDINSLyDVSRMYV | phosphorylation up-regulates activity | 7682059 | SIGNOR-249339 |
| LYN | PLCG2 | Tyr753 | ERDINSLyDVSRMYV | phosphorylation up-regulates activity | 7682059 | SIGNOR-249383 |
| HCK | PLCG2 | Tyr753 | ERDINSLyDVSRMYV | phosphorylation up-regulates activity | 7682059 | SIGNOR-249363 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BTK | phosphorylation up-regulates → | PLCG2 PTyr753 | phosphorylation up-regulates → | PLCG2 | 11507089 | SIGNOR-109754 |
| BTK | phosphorylation up-regulates → | PLCG2 PTyr753 | phosphorylation up-regulates → | PLCG2 | 11606584 | SIGNOR-111069 |
| LCK | phosphorylation up-regulates → | PLCG2 PTyr753 | phosphorylation up-regulates → | PLCG2 | 12181444 | SIGNOR-91473 |
| FYN | phosphorylation up-regulates → | PLCG2 PTyr753 | phosphorylation up-regulates → | PLCG2 | 7682059 | SIGNOR-249339 |
| LYN | phosphorylation up-regulates → | PLCG2 PTyr753 | phosphorylation up-regulates → | PLCG2 | 7682059 | SIGNOR-249383 |
| HCK | phosphorylation up-regulates → | PLCG2 PTyr753 | phosphorylation up-regulates → | PLCG2 | 7682059 | SIGNOR-249363 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| BTK | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-109754 |
| BTK | phosphorylation → up-regulates | PLCG2 | SIGNOR-111069 |
| LCK | phosphorylation → up-regulates | PLCG2 | SIGNOR-91473 |
| FYN | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-249339 |
| LYN | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-249383 |
| HCK | phosphorylation → up-regulates activity | PLCG2 | SIGNOR-249363 |
