Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MST1	PRKCA	Thr228	PQWNESFtFKLKPSD	phosphorylation up-regulates activity	26414765	SIGNOR-277178
SYK	PRKCA	Tyr658 View in OncoXplorer	SDFEGFSyVNPQFVH	phosphorylation up-regulates activity	12881490	SIGNOR-246581
PRKCA	PRKCA	Thr638 View in OncoXplorer	TRGQPVLtPPDQLVI	phosphorylation up-regulates	15277524	SIGNOR-127257
PDPK1	PRKCA	–		phosphorylation up-regulates	15209375	SIGNOR-126066
PLCG1	PRKCA	–		phosphorylation up-regulates	12645577	SIGNOR-99310
STK3	PRKCA	Ser226 View in OncoXplorer	LNPQWNEsFTFKLKP	phosphorylation up-regulates activity	26414765	SIGNOR-277177
PRKCA	PRKCA	Ser657 View in OncoXplorer	QSDFEGFsYVNPQFV	phosphorylation up-regulates	15277524	SIGNOR-127253
STK4	PRKCA	Thr228	PQWNESFtFKLKPSD	phosphorylation up-regulates activity	26414765	SIGNOR-280147
PHLPP2	PRKCA	Ser657 View in OncoXplorer	QSDFEGFsYVNPQFV	dephosphorylation down-regulates quantity	18162466	SIGNOR-237051
MST1	PRKCA	Ser226 View in OncoXplorer	LNPQWNEsFTFKLKP	phosphorylation up-regulates activity	26414765	SIGNOR-277179
STK4	PRKCA	Ser226 View in OncoXplorer	LNPQWNEsFTFKLKP	phosphorylation up-regulates activity	26414765	SIGNOR-280146
PHLPP1	PRKCA	Ser657 View in OncoXplorer	QSDFEGFsYVNPQFV	dephosphorylation down-regulates quantity	18162466	SIGNOR-237043
STK3	PRKCA	Thr228	PQWNESFtFKLKPSD	phosphorylation up-regulates activity	26414765	SIGNOR-277176

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MST1	phosphorylation up-regulates →	PRKCA PThr228	phosphorylation up-regulates →	PRKCA	26414765	SIGNOR-277178
SYK	phosphorylation up-regulates →	PRKCA PTyr658	phosphorylation up-regulates →	PRKCA	12881490	SIGNOR-246581
PRKCA	phosphorylation up-regulates →	PRKCA PThr638	phosphorylation up-regulates →	PRKCA	15277524	SIGNOR-127257
STK3	phosphorylation up-regulates →	PRKCA PSer226	phosphorylation up-regulates →	PRKCA	26414765	SIGNOR-277177
PRKCA	phosphorylation up-regulates →	PRKCA PSer657	phosphorylation up-regulates →	PRKCA	15277524	SIGNOR-127253
STK4	phosphorylation up-regulates →	PRKCA PThr228	phosphorylation up-regulates →	PRKCA	26414765	SIGNOR-280147
PHLPP2	dephosphorylation down-regulates ⊣	PRKCA PSer657	dephosphorylation up-regulates →	PRKCA	18162466	SIGNOR-237051
MST1	phosphorylation up-regulates →	PRKCA PSer226	phosphorylation up-regulates →	PRKCA	26414765	SIGNOR-277179
STK4	phosphorylation up-regulates →	PRKCA PSer226	phosphorylation up-regulates →	PRKCA	26414765	SIGNOR-280146
PHLPP1	dephosphorylation down-regulates ⊣	PRKCA PSer657	dephosphorylation up-regulates →	PRKCA	18162466	SIGNOR-237043
STK3	phosphorylation up-regulates →	PRKCA PThr228	phosphorylation up-regulates →	PRKCA	26414765	SIGNOR-277176

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MST1	phosphorylation → up-regulates activity	PRKCA	SIGNOR-277178
SYK	phosphorylation → up-regulates activity	PRKCA	SIGNOR-246581
PRKCA	phosphorylation → up-regulates	PRKCA	SIGNOR-127257
PDPK1	phosphorylation → up-regulates	PRKCA	SIGNOR-126066
PLCG1	phosphorylation → up-regulates	PRKCA	SIGNOR-99310
STK3	phosphorylation → up-regulates activity	PRKCA	SIGNOR-277177
PRKCA	phosphorylation → up-regulates	PRKCA	SIGNOR-127253
STK4	phosphorylation → up-regulates activity	PRKCA	SIGNOR-280147
PHLPP2	dephosphorylation → down-regulates quantity	PRKCA	SIGNOR-237051
MST1	phosphorylation → up-regulates activity	PRKCA	SIGNOR-277179
STK4	phosphorylation → up-regulates activity	PRKCA	SIGNOR-280146
PHLPP1	dephosphorylation → down-regulates quantity	PRKCA	SIGNOR-237043
STK3	phosphorylation → up-regulates activity	PRKCA	SIGNOR-277176