| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PHLPP2 | PRKCA | Ser657 | QSDFEGFsYVNPQFV | dephosphorylation down-regulates quantity | 18162466 | SIGNOR-237051 |
| PHLPP1 | PRKCA | Ser657 | QSDFEGFsYVNPQFV | dephosphorylation down-regulates quantity | 18162466 | SIGNOR-237043 |
| PRKCA | PRKCA | Ser657 | QSDFEGFsYVNPQFV | phosphorylation up-regulates | 15277524 | SIGNOR-127253 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PHLPP2 | dephosphorylation down-regulates ⊣ | PRKCA PSer657 | dephosphorylation up-regulates → | PRKCA | 18162466 | SIGNOR-237051 |
| PHLPP1 | dephosphorylation down-regulates ⊣ | PRKCA PSer657 | dephosphorylation up-regulates → | PRKCA | 18162466 | SIGNOR-237043 |
| PRKCA | phosphorylation up-regulates → | PRKCA PSer657 | phosphorylation up-regulates → | PRKCA | 15277524 | SIGNOR-127253 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PHLPP2 | dephosphorylation → down-regulates quantity | PRKCA | SIGNOR-237051 |
| PHLPP1 | dephosphorylation → down-regulates quantity | PRKCA | SIGNOR-237043 |
| PRKCA | phosphorylation → up-regulates | PRKCA | SIGNOR-127253 |
