| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinE/CDK2 | UBTF | Ser484 | ERGKLPEsPKRAEEI | phosphorylation up-regulates activity | 10202152 | SIGNOR-250755 |
| MAPK3 | UBTF | Thr117 | DFPKKPLtPYFRFFM | phosphorylation down-regulates | 11741541 | SIGNOR-112813 |
| MAPK1 | UBTF | Thr117 | DFPKKPLtPYFRFFM | phosphorylation down-regulates | 11741541 | SIGNOR-112805 |
| MAPK3 | UBTF | Thr201 | DIPEKPKtPQQLWYT | phosphorylation down-regulates | 11741541 | SIGNOR-112817 |
| MAPK1 | UBTF | Thr201 | DIPEKPKtPQQLWYT | phosphorylation down-regulates | 11741541 | SIGNOR-112809 |
| Gbeta | UBTF | – | phosphorylation down-regulates | 11741541 | SIGNOR-270080 | |
| ERK1/2 | UBTF | – | phosphorylation down-regulates | 11741541 | SIGNOR-270181 | |
| CyclinE/CDK2 | UBTF | Ser389 | INKKQATsPASKKPA | phosphorylation up-regulates | 11698641 | SIGNOR-216678 |
| CDK2 | UBTF | Ser389 | INKKQATsPASKKPA | phosphorylation up-regulates activity | 11698641 | SIGNOR-235419 |
| CyclinA2/CDK2 | UBTF | Ser389 | INKKQATsPASKKPA | phosphorylation up-regulates | 11698641 | SIGNOR-217304 |
| CyclinD/CDK4 | UBTF | Ser484 | ERGKLPEsPKRAEEI | phosphorylation up-regulates activity | 10202152 | SIGNOR-250754 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinE/CDK2 | phosphorylation up-regulates → | UBTF PSer484 | phosphorylation up-regulates → | UBTF | 10202152 | SIGNOR-250755 |
| MAPK3 | phosphorylation up-regulates → | UBTF PThr117 | phosphorylation down-regulates ⊣ | UBTF | 11741541 | SIGNOR-112813 |
| MAPK1 | phosphorylation up-regulates → | UBTF PThr117 | phosphorylation down-regulates ⊣ | UBTF | 11741541 | SIGNOR-112805 |
| MAPK3 | phosphorylation up-regulates → | UBTF PThr201 | phosphorylation down-regulates ⊣ | UBTF | 11741541 | SIGNOR-112817 |
| MAPK1 | phosphorylation up-regulates → | UBTF PThr201 | phosphorylation down-regulates ⊣ | UBTF | 11741541 | SIGNOR-112809 |
| CyclinE/CDK2 | phosphorylation up-regulates → | UBTF PSer389 | phosphorylation up-regulates → | UBTF | 11698641 | SIGNOR-216678 |
| CDK2 | phosphorylation up-regulates → | UBTF PSer389 | phosphorylation up-regulates → | UBTF | 11698641 | SIGNOR-235419 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | UBTF PSer389 | phosphorylation up-regulates → | UBTF | 11698641 | SIGNOR-217304 |
| CyclinD/CDK4 | phosphorylation up-regulates → | UBTF PSer484 | phosphorylation up-regulates → | UBTF | 10202152 | SIGNOR-250754 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinE/CDK2 | phosphorylation → up-regulates activity | UBTF | SIGNOR-250755 |
| MAPK3 | phosphorylation down-regulates | UBTF | SIGNOR-112813 |
| MAPK1 | phosphorylation down-regulates | UBTF | SIGNOR-112805 |
| MAPK3 | phosphorylation down-regulates | UBTF | SIGNOR-112817 |
| MAPK1 | phosphorylation down-regulates | UBTF | SIGNOR-112809 |
| Gbeta | phosphorylation down-regulates | UBTF | SIGNOR-270080 |
| ERK1/2 | phosphorylation down-regulates | UBTF | SIGNOR-270181 |
| CyclinE/CDK2 | phosphorylation → up-regulates | UBTF | SIGNOR-216678 |
| CDK2 | phosphorylation → up-regulates activity | UBTF | SIGNOR-235419 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | UBTF | SIGNOR-217304 |
| CyclinD/CDK4 | phosphorylation → up-regulates activity | UBTF | SIGNOR-250754 |
