| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | TAL1 | Ser122 | DGRMVQLsPPALAAP | phosphorylation down-regulates | 11904294 | SIGNOR-116153 |
| PRKACA | TAL1 | Ser122 | DGRMVQLsPPALAAP | phosphorylation down-regulates | 22310283 | SIGNOR-195987 |
| MAP2K1 | TAL1 | Ser122 | DGRMVQLsPPALAAP | phosphorylation down-regulates | 11904294 | SIGNOR-116149 |
| MEK1/2 | TAL1 | Ser122 | DGRMVQLsPPALAAP | phosphorylation down-regulates | 11904294 | SIGNOR-244975 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | TAL1 PSer122 | phosphorylation down-regulates ⊣ | TAL1 | 11904294 | SIGNOR-116153 |
| PRKACA | phosphorylation up-regulates → | TAL1 PSer122 | phosphorylation down-regulates ⊣ | TAL1 | 22310283 | SIGNOR-195987 |
| MAP2K1 | phosphorylation up-regulates → | TAL1 PSer122 | phosphorylation down-regulates ⊣ | TAL1 | 11904294 | SIGNOR-116149 |
| MEK1/2 | phosphorylation up-regulates → | TAL1 PSer122 | phosphorylation down-regulates ⊣ | TAL1 | 11904294 | SIGNOR-244975 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation down-regulates | TAL1 | SIGNOR-116153 |
| PRKACA | phosphorylation down-regulates | TAL1 | SIGNOR-195987 |
| MAP2K1 | phosphorylation down-regulates | TAL1 | SIGNOR-116149 |
| MEK1/2 | phosphorylation down-regulates | TAL1 | SIGNOR-244975 |
