| Name | DES |
| ID | P17661 |
| Role | substrate |
| Enzymatic Domains |
IF rod 108-416 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKB | DES | Thr17 | RVSSYRRtFGGAPGF | phosphorylation down-regulates | 12686604 | SIGNOR-100115 |
| ROCK1 | DES | Thr17 | RVSSYRRtFGGAPGF | phosphorylation down-regulates | 12686604 | SIGNOR-100177 |
| ROCK1 | DES | Thr77 | RASRLGTtRTPSSYG | phosphorylation unknown | 10574968 | SIGNOR-249033 |
| CDK1 | DES | Ser31 | FPLGSPLsSPVFPRA | phosphorylation down-regulates quantity by destabilization | 32042098 | SIGNOR-278331 |
| ROCK1 | DES | Thr76 | LRASRLGtTRTPSSY | phosphorylation unknown | 10574968 | SIGNOR-249031 |
| AURKB | DES | Ser12 | YSSSQRVsSYRRTFG | phosphorylation down-regulates | 12686604 | SIGNOR-100107 |
| ROCK1 | DES | Thr17 | RVSSYRRtFGGAPGF | phosphorylation unknown | 10574968 | SIGNOR-249032 |
| AURKB | DES | Ser60 | VYQVSRTsGGAGGLG | phosphorylation down-regulates | 12686604 | SIGNOR-100111 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKB | phosphorylation up-regulates → | DES PThr17 | phosphorylation down-regulates ⊣ | DES | 12686604 | SIGNOR-100115 |
| ROCK1 | phosphorylation up-regulates → | DES PThr17 | phosphorylation down-regulates ⊣ | DES | 12686604 | SIGNOR-100177 |
| ROCK1 | phosphorylation up-regulates → | DES PThr77 | phosphorylation down-regulates ⊣ | DES | 10574968 | SIGNOR-249033 |
| CDK1 | phosphorylation up-regulates → | DES PSer31 | phosphorylation down-regulates ⊣ | DES | 32042098 | SIGNOR-278331 |
| ROCK1 | phosphorylation up-regulates → | DES PThr76 | phosphorylation down-regulates ⊣ | DES | 10574968 | SIGNOR-249031 |
| AURKB | phosphorylation up-regulates → | DES PSer12 | phosphorylation down-regulates ⊣ | DES | 12686604 | SIGNOR-100107 |
| ROCK1 | phosphorylation up-regulates → | DES PThr17 | phosphorylation down-regulates ⊣ | DES | 10574968 | SIGNOR-249032 |
| AURKB | phosphorylation up-regulates → | DES PSer60 | phosphorylation down-regulates ⊣ | DES | 12686604 | SIGNOR-100111 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AURKB | phosphorylation down-regulates | DES | SIGNOR-100115 |
| ROCK1 | phosphorylation down-regulates | DES | SIGNOR-100177 |
| ROCK1 | phosphorylation → unknown | DES | SIGNOR-249033 |
| CDK1 | phosphorylation down-regulates quantity by destabilization | DES | SIGNOR-278331 |
| ROCK1 | phosphorylation → unknown | DES | SIGNOR-249031 |
| AURKB | phosphorylation down-regulates | DES | SIGNOR-100107 |
| ROCK1 | phosphorylation → unknown | DES | SIGNOR-249032 |
| AURKB | phosphorylation down-regulates | DES | SIGNOR-100111 |