| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ROCK1 | DES | Thr17 | RVSSYRRtFGGAPGF | phosphorylation unknown | 10574968 | SIGNOR-249032 |
| AURKB | DES | Thr17 | RVSSYRRtFGGAPGF | phosphorylation down-regulates | 12686604 | SIGNOR-100115 |
| ROCK1 | DES | Thr17 | RVSSYRRtFGGAPGF | phosphorylation down-regulates | 12686604 | SIGNOR-100177 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ROCK1 | phosphorylation up-regulates → | DES PThr17 | phosphorylation down-regulates ⊣ | DES | 10574968 | SIGNOR-249032 |
| AURKB | phosphorylation up-regulates → | DES PThr17 | phosphorylation down-regulates ⊣ | DES | 12686604 | SIGNOR-100115 |
| ROCK1 | phosphorylation up-regulates → | DES PThr17 | phosphorylation down-regulates ⊣ | DES | 12686604 | SIGNOR-100177 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ROCK1 | phosphorylation → unknown | DES | SIGNOR-249032 |
| AURKB | phosphorylation down-regulates | DES | SIGNOR-100115 |
| ROCK1 | phosphorylation down-regulates | DES | SIGNOR-100177 |
