Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
ROCK1	DES	Thr17 View in OncoXplorer	RVSSYRRtFGGAPGF	phosphorylation down-regulates	12686604	SIGNOR-100177
AURKB	DES	Thr17 View in OncoXplorer	RVSSYRRtFGGAPGF	phosphorylation down-regulates	12686604	SIGNOR-100115
ROCK1	DES	Thr17 View in OncoXplorer	RVSSYRRtFGGAPGF	phosphorylation unknown	10574968	SIGNOR-249032

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
ROCK1	phosphorylation up-regulates →	DES PThr17	phosphorylation down-regulates ⊣	DES	12686604	SIGNOR-100177
AURKB	phosphorylation up-regulates →	DES PThr17	phosphorylation down-regulates ⊣	DES	12686604	SIGNOR-100115
ROCK1	phosphorylation up-regulates →	DES PThr17	phosphorylation down-regulates ⊣	DES	10574968	SIGNOR-249032

Regulator	Mechanism/Effect	Target	SIGNOR-ID
ROCK1	phosphorylation down-regulates	DES	SIGNOR-100177
AURKB	phosphorylation down-regulates	DES	SIGNOR-100115
ROCK1	phosphorylation → unknown	DES	SIGNOR-249032