| Name | PTPN2 |
| ID | P17706 |
| Role | phosphatase |
| Enzymatic Domains |
Tyrosine-protein phosphatase 5-275 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN2 | WASL | Tyr256 | RETSKVIyDFIEKTG | dephosphorylation down-regulates | 16293614 | SIGNOR-141652 |
| PTPN2 | BCL2L11 | – | dephosphorylation up-regulates activity | 21984578 | SIGNOR-277055 | |
| PTPN2 | EGFR | – | dephosphorylation down-regulates | 11514572 | SIGNOR-109804 | |
| PTPN2 | EGFR | – | dephosphorylation down-regulates | 15592458 | SIGNOR-132316 | |
| PTPN2 | KRAS | – | dephosphorylation down-regulates activity | 33122197 | SIGNOR-277039 | |
| PTPN2 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates | 10734133 | SIGNOR-75910 |
| PTPN2 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates | 10734133 | SIGNOR-75914 |
| PTPN2 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 10734133 | SIGNOR-75918 |
| PTPN2 | INSR | Tyr999 | YASSNPEyLSASDVF | dephosphorylation down-regulates | 10734133 | SIGNOR-75922 |
| PTPN2 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates | 1373652 | SIGNOR-18018 |
| PTPN2 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates activity | 12612081 | SIGNOR-248385 |
| PTPN2 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates activity | 12612081 | SIGNOR-248386 |
| PTPN2 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates activity | 30230471 | SIGNOR-276956 |
| PTPN2 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates activity | 30230471 | SIGNOR-276957 |
| PTPN2 | FYN | Tyr420 | RLIEDNEyTARQGAK | dephosphorylation down-regulates | 22080863 | SIGNOR-177113 |
| PTPN2 | MET | Tyr1234 | RDMYDKEyYSVHNKT | dephosphorylation down-regulates | 18819921 | SIGNOR-181331 |
| PTPN2 | MET | Tyr1235 | DMYDKEYySVHNKTG | dephosphorylation down-regulates | 18819921 | SIGNOR-181335 |
| PTPN2 | MET | Tyr1234 | RDMYDKEyYSVHNKT | dephosphorylation down-regulates activity | 18819921 | SIGNOR-248387 |
| PTPN2 | MET | Tyr1235 | DMYDKEYySVHNKTG | dephosphorylation down-regulates activity | 18819921 | SIGNOR-248388 |
| PTPN2 | PDGFRB | Tyr1021 | PNEGDNDyIIPLPDP | dephosphorylation down-regulates activity | 14966296 | SIGNOR-248390 |
| PTPN2 | PDGFRB | Tyr771 | ADIESSNyMAPYDNY | dephosphorylation down-regulates activity | 14966296 | SIGNOR-248389 |
| PTPN2 | GHR | Tyr332 | ILAIHDSyKPEFHSD | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248391 |
| PTPN2 | GHR | Tyr487 | SLSNIDFyAQVSDIT | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248392 |
| PTPN2 | GHR | Tyr534 | NFLMDNAyFCEADAK | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248393 |
| PTPN2 | GHR | Tyr566 | SLNQEDIyITTESLT | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248394 |
| PTPN2 | SRC | – | dephosphorylation down-regulates | 22080863 | SIGNOR-177116 | |
| PTPN2 | SRC | – | dephosphorylation down-regulates activity | 33603165 | SIGNOR-276996 | |
| PTPN2 | GJA1 | Tyr247 | VKGKSDPyHATSGAL | dephosphorylation up-regulates | 24849651 | SIGNOR-205097 |
| PTPN2 | GJA1 | Tyr265 | KDCGSQKyAYFNGCS | dephosphorylation up-regulates | 24849651 | SIGNOR-205101 |
| PTPN2 | JAK1 | Tyr1034 | AIETDKEyYTVKDDR | dephosphorylation down-regulates activity | 11909529 | SIGNOR-248395 |
| PTPN2 | JAK1 | Tyr1035 | IETDKEYyTVKDDRD | dephosphorylation down-regulates activity | 11909529 | SIGNOR-248396 |
| PTPN2 | JAK1 | – | dephosphorylation down-regulates activity | 15780598 | SIGNOR-134620 | |
| PTPN2 | SHC1 | Tyr349 | EEPPDHQyYNDFPGK | dephosphorylation down-regulates activity | 9488479 | SIGNOR-248397 |
| PTPN2 | KDR | Tyr1214 | VCDPKFHyDNTAGIS | dephosphorylation down-regulates | 18840653 | SIGNOR-181546 |
| PTPN2 | KDR | Tyr996 | EEAPEDLyKDFLTLE | dephosphorylation down-regulates | 18840653 | SIGNOR-181550 |
| PTPN2 | KDR | Tyr1054 | FGLARDIyKDPDYVR | dephosphorylation down-regulates activity | 18840653 | SIGNOR-248399 |
| PTPN2 | KDR | Tyr1059 | DIYKDPDyVRKGDAR | dephosphorylation down-regulates activity | 18840653 | SIGNOR-248400 |
| PTPN2 | KDR | Tyr1214 | VCDPKFHyDNTAGIS | dephosphorylation down-regulates activity | 18840653 | SIGNOR-248401 |
| PTPN2 | KDR | Tyr1059 | DIYKDPDyVRKGDAR | dephosphorylation down-regulates activity | 29955047 | SIGNOR-276962 |
| PTPN2 | KDR | Tyr1175 | AQQDGKDyIVLPISE | dephosphorylation down-regulates activity | 29955047 | SIGNOR-276961 |
| PTPN2 | KDR | Tyr996 | EEAPEDLyKDFLTLE | dephosphorylation unknown | 18840653 | SIGNOR-248398 |
| PTPN2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates | 12138178 | SIGNOR-90818 |
| PTPN2 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 15780598 | SIGNOR-93998 |
| PTPN2 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | dephosphorylation down-regulates | 12138178 | SIGNOR-90814 |
| PTPN2 | STAT1 | Tyr701 | DGPKGTGyIKTELIS | dephosphorylation down-regulates activity | 12138178 | SIGNOR-248402 |
| PTPN2 | STAT1 | – | dephosphorylation down-regulates activity | 15780598 | SIGNOR-133279 | |
| PTPN2 | STAT6 | – | dephosphorylation down-regulates activity | 17210636 | SIGNOR-235192 | |
| PTPN2 | STAT5A | – | dephosphorylation down-regulates activity | 15780598 | SIGNOR-133547 | |
| PTPN2 | STAT5B | – | dephosphorylation down-regulates activity | 12359225 | SIGNOR-277126 | |
| PTPN2 | JAK3 | – | dephosphorylation down-regulates activity | 15780598 | SIGNOR-133078 | |
| PTPN2 | FKBP4 | – | dephosphorylation down-regulates | 12552015 | SIGNOR-97794 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN2 | dephosphorylation down-regulates ⊣ | WASL PTyr256 | dephosphorylation up-regulates → | WASL | 16293614 | SIGNOR-141652 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75910 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75914 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75918 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr999 | dephosphorylation up-regulates → | INSR | 10734133 | SIGNOR-75922 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 1373652 | SIGNOR-18018 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 12612081 | SIGNOR-248385 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 12612081 | SIGNOR-248386 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 30230471 | SIGNOR-276956 |
| PTPN2 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 30230471 | SIGNOR-276957 |
| PTPN2 | dephosphorylation down-regulates ⊣ | FYN PTyr420 | dephosphorylation up-regulates → | FYN | 22080863 | SIGNOR-177113 |
| PTPN2 | dephosphorylation down-regulates ⊣ | MET PTyr1234 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-181331 |
| PTPN2 | dephosphorylation down-regulates ⊣ | MET PTyr1235 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-181335 |
| PTPN2 | dephosphorylation down-regulates ⊣ | MET PTyr1234 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-248387 |
| PTPN2 | dephosphorylation down-regulates ⊣ | MET PTyr1235 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-248388 |
| PTPN2 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr1021 | dephosphorylation up-regulates → | PDGFRB | 14966296 | SIGNOR-248390 |
| PTPN2 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr771 | dephosphorylation up-regulates → | PDGFRB | 14966296 | SIGNOR-248389 |
| PTPN2 | dephosphorylation down-regulates ⊣ | GHR PTyr332 | dephosphorylation up-regulates → | GHR | 12907755 | SIGNOR-248391 |
| PTPN2 | dephosphorylation down-regulates ⊣ | GHR PTyr487 | dephosphorylation up-regulates → | GHR | 12907755 | SIGNOR-248392 |
| PTPN2 | dephosphorylation down-regulates ⊣ | GHR PTyr534 | dephosphorylation up-regulates → | GHR | 12907755 | SIGNOR-248393 |
| PTPN2 | dephosphorylation down-regulates ⊣ | GHR PTyr566 | dephosphorylation up-regulates → | GHR | 12907755 | SIGNOR-248394 |
| PTPN2 | dephosphorylation down-regulates ⊣ | GJA1 PTyr247 | dephosphorylation down-regulates ⊣ | GJA1 | 24849651 | SIGNOR-205097 |
| PTPN2 | dephosphorylation down-regulates ⊣ | GJA1 PTyr265 | dephosphorylation down-regulates ⊣ | GJA1 | 24849651 | SIGNOR-205101 |
| PTPN2 | dephosphorylation down-regulates ⊣ | JAK1 PTyr1034 | dephosphorylation up-regulates → | JAK1 | 11909529 | SIGNOR-248395 |
| PTPN2 | dephosphorylation down-regulates ⊣ | JAK1 PTyr1035 | dephosphorylation up-regulates → | JAK1 | 11909529 | SIGNOR-248396 |
| PTPN2 | dephosphorylation down-regulates ⊣ | SHC1 PTyr349 | dephosphorylation up-regulates → | SHC1 | 9488479 | SIGNOR-248397 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr1214 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-181546 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr996 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-181550 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr1054 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-248399 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr1059 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-248400 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr1214 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-248401 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr1059 | dephosphorylation up-regulates → | KDR | 29955047 | SIGNOR-276962 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr1175 | dephosphorylation up-regulates → | KDR | 29955047 | SIGNOR-276961 |
| PTPN2 | dephosphorylation down-regulates ⊣ | KDR PTyr996 | dephosphorylation up-regulates → | KDR | 18840653 | SIGNOR-248398 |
| PTPN2 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 12138178 | SIGNOR-90818 |
| PTPN2 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 15780598 | SIGNOR-93998 |
| PTPN2 | dephosphorylation down-regulates ⊣ | STAT1 PTyr701 | dephosphorylation up-regulates → | STAT1 | 12138178 | SIGNOR-90814 |
| PTPN2 | dephosphorylation down-regulates ⊣ | STAT1 PTyr701 | dephosphorylation up-regulates → | STAT1 | 12138178 | SIGNOR-248402 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN2 | dephosphorylation down-regulates | WASL | SIGNOR-141652 |
| PTPN2 | dephosphorylation → up-regulates activity | BCL2L11 | SIGNOR-277055 |
| PTPN2 | dephosphorylation down-regulates | EGFR | SIGNOR-109804 |
| PTPN2 | dephosphorylation down-regulates | EGFR | SIGNOR-132316 |
| PTPN2 | dephosphorylation → down-regulates activity | KRAS | SIGNOR-277039 |
| PTPN2 | dephosphorylation down-regulates | INSR | SIGNOR-75910 |
| PTPN2 | dephosphorylation down-regulates | INSR | SIGNOR-75914 |
| PTPN2 | dephosphorylation down-regulates | INSR | SIGNOR-75918 |
| PTPN2 | dephosphorylation down-regulates | INSR | SIGNOR-75922 |
| PTPN2 | dephosphorylation down-regulates | INSR | SIGNOR-18018 |
| PTPN2 | dephosphorylation → down-regulates activity | INSR | SIGNOR-248385 |
| PTPN2 | dephosphorylation → down-regulates activity | INSR | SIGNOR-248386 |
| PTPN2 | dephosphorylation → down-regulates activity | INSR | SIGNOR-276956 |
| PTPN2 | dephosphorylation → down-regulates activity | INSR | SIGNOR-276957 |
| PTPN2 | dephosphorylation down-regulates | FYN | SIGNOR-177113 |
| PTPN2 | dephosphorylation down-regulates | MET | SIGNOR-181331 |
| PTPN2 | dephosphorylation down-regulates | MET | SIGNOR-181335 |
| PTPN2 | dephosphorylation → down-regulates activity | MET | SIGNOR-248387 |
| PTPN2 | dephosphorylation → down-regulates activity | MET | SIGNOR-248388 |
| PTPN2 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248390 |
| PTPN2 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248389 |
| PTPN2 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248391 |
| PTPN2 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248392 |
| PTPN2 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248393 |
| PTPN2 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248394 |
| PTPN2 | dephosphorylation down-regulates | SRC | SIGNOR-177116 |
| PTPN2 | dephosphorylation → down-regulates activity | SRC | SIGNOR-276996 |
| PTPN2 | dephosphorylation → up-regulates | GJA1 | SIGNOR-205097 |
| PTPN2 | dephosphorylation → up-regulates | GJA1 | SIGNOR-205101 |
| PTPN2 | dephosphorylation → down-regulates activity | JAK1 | SIGNOR-248395 |
| PTPN2 | dephosphorylation → down-regulates activity | JAK1 | SIGNOR-248396 |
| PTPN2 | dephosphorylation → down-regulates activity | JAK1 | SIGNOR-134620 |
| PTPN2 | dephosphorylation → down-regulates activity | SHC1 | SIGNOR-248397 |
| PTPN2 | dephosphorylation down-regulates | KDR | SIGNOR-181546 |
| PTPN2 | dephosphorylation down-regulates | KDR | SIGNOR-181550 |
| PTPN2 | dephosphorylation → down-regulates activity | KDR | SIGNOR-248399 |
| PTPN2 | dephosphorylation → down-regulates activity | KDR | SIGNOR-248400 |
| PTPN2 | dephosphorylation → down-regulates activity | KDR | SIGNOR-248401 |
| PTPN2 | dephosphorylation → down-regulates activity | KDR | SIGNOR-276962 |
| PTPN2 | dephosphorylation → down-regulates activity | KDR | SIGNOR-276961 |
| PTPN2 | dephosphorylation → unknown | KDR | SIGNOR-248398 |
| PTPN2 | dephosphorylation down-regulates | STAT3 | SIGNOR-90818 |
| PTPN2 | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-93998 |
| PTPN2 | dephosphorylation down-regulates | STAT1 | SIGNOR-90814 |
| PTPN2 | dephosphorylation → down-regulates activity | STAT1 | SIGNOR-248402 |
| PTPN2 | dephosphorylation → down-regulates activity | STAT1 | SIGNOR-133279 |
| PTPN2 | dephosphorylation → down-regulates activity | STAT6 | SIGNOR-235192 |
| PTPN2 | dephosphorylation → down-regulates activity | STAT5A | SIGNOR-133547 |
| PTPN2 | dephosphorylation → down-regulates activity | STAT5B | SIGNOR-277126 |
| PTPN2 | dephosphorylation → down-regulates activity | JAK3 | SIGNOR-133078 |
| PTPN2 | dephosphorylation down-regulates | FKBP4 | SIGNOR-97794 |