| Name | CTPS1 |
| ID | P17812 |
| Role | substrate |
| Enzymatic Domains |
Glutamine amidotransferase type-1 300-554 |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | CTPS1 | Ser462 | TLFQTKNsVMRKLYG | phosphorylation up-regulates | 17463002 | SIGNOR-154617 |
| GSK3B | CTPS1 | Ser575 | SDRSGSSsPDSEITE | phosphorylation down-regulates activity | 17681942 | SIGNOR-276069 |
| PRKCA | CTPS1 | Thr455 | MRLGKRRtLFQTKNS | phosphorylation down-regulates | 17463002 | SIGNOR-154621 |
| GSK3B | CTPS1 | Ser574 | YSDRSGSsSPDSEIT | phosphorylation down-regulates activity | 17681942 | SIGNOR-276068 |
| GSK3B | CTPS1 | Ser571 | RDTYSDRsGSSSPDS | phosphorylation down-regulates activity | 17681942 | SIGNOR-276070 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | CTPS1 PSer462 | phosphorylation up-regulates → | CTPS1 | 17463002 | SIGNOR-154617 |
| GSK3B | phosphorylation up-regulates → | CTPS1 PSer575 | phosphorylation down-regulates ⊣ | CTPS1 | 17681942 | SIGNOR-276069 |
| PRKCA | phosphorylation up-regulates → | CTPS1 PThr455 | phosphorylation down-regulates ⊣ | CTPS1 | 17463002 | SIGNOR-154621 |
| GSK3B | phosphorylation up-regulates → | CTPS1 PSer574 | phosphorylation down-regulates ⊣ | CTPS1 | 17681942 | SIGNOR-276068 |
| GSK3B | phosphorylation up-regulates → | CTPS1 PSer571 | phosphorylation down-regulates ⊣ | CTPS1 | 17681942 | SIGNOR-276070 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation → up-regulates | CTPS1 | SIGNOR-154617 |
| GSK3B | phosphorylation → down-regulates activity | CTPS1 | SIGNOR-276069 |
| PRKCA | phosphorylation down-regulates | CTPS1 | SIGNOR-154621 |
| GSK3B | phosphorylation → down-regulates activity | CTPS1 | SIGNOR-276068 |
| GSK3B | phosphorylation → down-regulates activity | CTPS1 | SIGNOR-276070 |