Entity Details

Name XBP1
ID P17861
Role substrate
Enzymatic Domains
bZIP 70-133
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ERK1/2XBP1Ser181QQVQAQLsPLQNISPphosphorylation
down-regulates quantity by destabilization		23277279SIGNOR-276439
ERK1/2XBP1Ser68
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RQRLTHLsPEEKALRphosphorylation
down-regulates quantity by destabilization		23277279SIGNOR-276438
ERN1XBP1–phosphorylation
up-regulates activity		36001995SIGNOR-279712
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ERK1/2phosphorylation
up-regulates
→
XBP1
PSer181		phosphorylation
down-regulates
⊣		XBP123277279SIGNOR-276439
ERK1/2phosphorylation
up-regulates
→
XBP1
PSer68		phosphorylation
down-regulates
⊣		XBP123277279SIGNOR-276438
Regulator Mechanism/Effect Target SIGNOR-ID
ERK1/2phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		XBP1SIGNOR-276439
ERK1/2phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		XBP1SIGNOR-276438
ERN1phosphorylation
→
up-regulates activity 		XBP1SIGNOR-279712