| Name | FLT1 |
| ID | P17948 |
| Role | kinase |
| Enzymatic Domains |
Ig-like C2-type 1 32-123
Ig-like C2-type 2 151-214
Ig-like C2-type 3 230-327
Ig-like C2-type 4 335-421
Ig-like C2-type 5 428-553
Ig-like C2-type 6 556-654
Ig-like C2-type 7 661-747
Protein kinase 827-1158 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FLT1 | FLT1 | Tyr1213 | GSSDDVRyVNAFKFM | phosphorylation up-regulates | 11583921 | SIGNOR-110850 |
| FLT1 | FLT1 | Tyr1169 | VQQDGKDyIPINAIL | phosphorylation up-regulates | 9299537 | SIGNOR-50834 |
| FLT1 | FLT1 | Tyr1213 | GSSDDVRyVNAFKFM | phosphorylation up-regulates | 9722576 | SIGNOR-59750 |
| FLT1 | FLT1 | Tyr1242 | ATSMFDDyQGDSSTL | phosphorylation up-regulates | 9722576 | SIGNOR-59754 |
| FLT1 | FLT1 | Tyr1327 | CCSPPPDyNSVVLYS | phosphorylation up-regulates | 9722576 | SIGNOR-59758 |
| FLT1 | FLT1 | Tyr1333 | DYNSVVLySTPPI | phosphorylation up-regulates | 9722576 | SIGNOR-59762 |
| FLT1 | GNAI1 | Tyr154 | QLNDSAAyYLNDLDR | phosphorylation up-regulates activity | 33139573 | SIGNOR-277230 |
| FLT1 | GNAI1 | Tyr155 | LNDSAAYyLNDLDRI | phosphorylation up-regulates activity | 33139573 | SIGNOR-277229 |
| FLT1 | GNAI1 | Tyr320 | RKDTKEIyTHFTCAT | phosphorylation up-regulates activity | 33139573 | SIGNOR-277231 |
| FLT1 | GLO1 | Tyr136 | GIAVPDVySACKRFE | phosphorylation up-regulates activity | 34838714 | SIGNOR-276190 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FLT1 | phosphorylation up-regulates → | FLT1 PTyr1213 | phosphorylation up-regulates → | FLT1 | 11583921 | SIGNOR-110850 |
| FLT1 | phosphorylation up-regulates → | FLT1 PTyr1169 | phosphorylation up-regulates → | FLT1 | 9299537 | SIGNOR-50834 |
| FLT1 | phosphorylation up-regulates → | FLT1 PTyr1213 | phosphorylation up-regulates → | FLT1 | 9722576 | SIGNOR-59750 |
| FLT1 | phosphorylation up-regulates → | FLT1 PTyr1242 | phosphorylation up-regulates → | FLT1 | 9722576 | SIGNOR-59754 |
| FLT1 | phosphorylation up-regulates → | FLT1 PTyr1327 | phosphorylation up-regulates → | FLT1 | 9722576 | SIGNOR-59758 |
| FLT1 | phosphorylation up-regulates → | FLT1 PTyr1333 | phosphorylation up-regulates → | FLT1 | 9722576 | SIGNOR-59762 |
| FLT1 | phosphorylation up-regulates → | GNAI1 PTyr154 | phosphorylation up-regulates → | GNAI1 | 33139573 | SIGNOR-277230 |
| FLT1 | phosphorylation up-regulates → | GNAI1 PTyr155 | phosphorylation up-regulates → | GNAI1 | 33139573 | SIGNOR-277229 |
| FLT1 | phosphorylation up-regulates → | GNAI1 PTyr320 | phosphorylation up-regulates → | GNAI1 | 33139573 | SIGNOR-277231 |
| FLT1 | phosphorylation up-regulates → | GLO1 PTyr136 | phosphorylation up-regulates → | GLO1 | 34838714 | SIGNOR-276190 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FLT1 | phosphorylation → up-regulates | FLT1 | SIGNOR-110850 |
| FLT1 | phosphorylation → up-regulates | FLT1 | SIGNOR-50834 |
| FLT1 | phosphorylation → up-regulates | FLT1 | SIGNOR-59750 |
| FLT1 | phosphorylation → up-regulates | FLT1 | SIGNOR-59754 |
| FLT1 | phosphorylation → up-regulates | FLT1 | SIGNOR-59758 |
| FLT1 | phosphorylation → up-regulates | FLT1 | SIGNOR-59762 |
| FLT1 | phosphorylation → up-regulates activity | GNAI1 | SIGNOR-277230 |
| FLT1 | phosphorylation → up-regulates activity | GNAI1 | SIGNOR-277229 |
| FLT1 | phosphorylation → up-regulates activity | GNAI1 | SIGNOR-277231 |
| FLT1 | phosphorylation → up-regulates activity | GLO1 | SIGNOR-276190 |