| Name | PTPN1 |
| ID | P18031 |
| Role | phosphatase |
| Enzymatic Domains |
Tyrosine-protein phosphatase 3-277 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | LAT | – | dephosphorylation down-regulates | 12857726 | SIGNOR-103599 | |
| PTPN1 | LAT | – | dephosphorylation down-regulates activity | 12857726 | SIGNOR-248403 | |
| PTPN1 | JAK2 | Tyr1008 | LPQDKEYyKVKEPGE | dephosphorylation down-regulates | 15780598 | SIGNOR-133852 |
| PTPN1 | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | dephosphorylation down-regulates | 15821101 | SIGNOR-134955 |
| PTPN1 | JAK2 | – | dephosphorylation down-regulates | 15821101 | SIGNOR-135207 | |
| PTPN1 | JAK2 | Tyr1007 | VLPQDKEyYKVKEPG | dephosphorylation down-regulates activity | 11970898 | SIGNOR-248404 |
| PTPN1 | JAK2 | Tyr1008 | LPQDKEYyKVKEPGE | dephosphorylation down-regulates activity | 11970898 | SIGNOR-248405 |
| PTPN1 | STAM2 | Tyr291 | KSEPEPVyIDEDKMD | dephosphorylation up-regulates quantity by stabilization | 20504764 | SIGNOR-248406 |
| PTPN1 | ABL1 | – | dephosphorylation down-regulates | 9566916 | SIGNOR-56815 | |
| PTPN1 | EGFR | – | dephosphorylation down-regulates activity | 18253097 | SIGNOR-276981 | |
| PTPN1 | EGFR | Tyr1016 | DVVDADEyLIPQQGF | dephosphorylation down-regulates activity | 8621392 | SIGNOR-248407 |
| PTPN1 | NTRK1 | – | dephosphorylation down-regulates activity | 28919207 | SIGNOR-277081 | |
| PTPN1 | KRT8 | Tyr267 | IAEVKAQyEDIANRS | dephosphorylation down-regulates activity | 24003221 | SIGNOR-265495 |
| PTPN1 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates activity | 11579209 | SIGNOR-235495 |
| PTPN1 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates activity | 11579209 | SIGNOR-235499 |
| PTPN1 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates activity | 11579209 | SIGNOR-235503 |
| PTPN1 | INSR | Tyr1185 | FGMTRDIyETDYYRK | dephosphorylation down-regulates activity | 16582879 | SIGNOR-248408 |
| PTPN1 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates activity | 16582879 | SIGNOR-248409 |
| PTPN1 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates activity | 16582879 | SIGNOR-248410 |
| PTPN1 | INSR | Tyr1189 | RDIYETDyYRKGGKG | dephosphorylation down-regulates activity | 22124607 | SIGNOR-276947 |
| PTPN1 | INSR | Tyr1190 | DIYETDYyRKGGKGL | dephosphorylation down-regulates activity | 22124607 | SIGNOR-276946 |
| PTPN1 | IGF1R | – | dephosphorylation down-regulates activity | 11884589 | SIGNOR-115709 | |
| PTPN1 | MET | Tyr1234 | RDMYDKEyYSVHNKT | dephosphorylation down-regulates | 16537444 | SIGNOR-145141 |
| PTPN1 | MET | Tyr1235 | DMYDKEYySVHNKTG | dephosphorylation down-regulates | 16537444 | SIGNOR-145145 |
| PTPN1 | MET | Tyr1234 | RDMYDKEyYSVHNKT | dephosphorylation down-regulates | 18819921 | SIGNOR-181323 |
| PTPN1 | MET | Tyr1235 | DMYDKEYySVHNKTG | dephosphorylation down-regulates | 18819921 | SIGNOR-181327 |
| PTPN1 | MET | Tyr1234 | RDMYDKEyYSVHNKT | dephosphorylation down-regulates activity | 18819921 | SIGNOR-248411 |
| PTPN1 | MET | Tyr1235 | DMYDKEYySVHNKTG | dephosphorylation down-regulates activity | 18819921 | SIGNOR-248412 |
| PTPN1 | MET | – | dephosphorylation down-regulates activity | 29920310 | SIGNOR-277001 | |
| PTPN1 | ROS1 | Tyr2110 | FGLARDIyKNDYYRK | dephosphorylation down-regulates | 17416557 | SIGNOR-154199 |
| PTPN1 | ROS1 | Tyr2114 | RDIYKNDyYRKRGEG | dephosphorylation down-regulates | 17416557 | SIGNOR-154203 |
| PTPN1 | ROS1 | Tyr2115 | DIYKNDYyRKRGEGL | dephosphorylation down-regulates | 17416557 | SIGNOR-154207 |
| PTPN1 | PDGFRB | Tyr1009 | LDTSSVLyTAVQPNE | dephosphorylation down-regulates | 18567737 | SIGNOR-179064 |
| PTPN1 | PDGFRB | Tyr1021 | PNEGDNDyIIPLPDP | dephosphorylation down-regulates | 18567737 | SIGNOR-179068 |
| PTPN1 | PDGFRB | Tyr716 | RPPSAELySNALPVG | dephosphorylation down-regulates | 18567737 | SIGNOR-179072 |
| PTPN1 | PDGFRB | Tyr751 | SKDESVDyVPMLDMK | dephosphorylation down-regulates | 18567737 | SIGNOR-179076 |
| PTPN1 | PDGFRB | Tyr771 | ADIESSNyMAPYDNY | dephosphorylation down-regulates | 18567737 | SIGNOR-179080 |
| PTPN1 | PDGFRB | Tyr1009 | LDTSSVLyTAVQPNE | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248416 |
| PTPN1 | PDGFRB | Tyr1021 | PNEGDNDyIIPLPDP | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248417 |
| PTPN1 | PDGFRB | Tyr740 | TGESDGGyMDMSKDE | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248413 |
| PTPN1 | PDGFRB | Tyr751 | SKDESVDyVPMLDMK | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248414 |
| PTPN1 | PDGFRB | Tyr771 | ADIESSNyMAPYDNY | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248415 |
| PTPN1 | GHR | Tyr332 | ILAIHDSyKPEFHSD | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248418 |
| PTPN1 | GHR | Tyr487 | SLSNIDFyAQVSDIT | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248419 |
| PTPN1 | GHR | Tyr534 | NFLMDNAyFCEADAK | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248420 |
| PTPN1 | GHR | Tyr566 | SLNQEDIyITTESLT | dephosphorylation down-regulates activity | 12907755 | SIGNOR-248421 |
| PTPN1 | BCR | – | dephosphorylation down-regulates | 9566916 | SIGNOR-56818 | |
| PTPN1 | ACTN1 | Tyr12 | DSQQTNDyMQPEEDW | dephosphorylation down-regulates activity | 16291744 | SIGNOR-270539 |
| PTPN1 | ACTN1 | Tyr12 | DSQQTNDyMQPEEDW | dephosphorylation up-regulates | 16291744 | SIGNOR-141634 |
| PTPN1 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates | 12857726 | SIGNOR-103607 |
| PTPN1 | SRC | Tyr419 | RLIEDNEyTARQGAK | dephosphorylation up-regulates activity | 11007774 | SIGNOR-245299 |
| PTPN1 | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 17974954 | SIGNOR-248422 |
| PTPN1 | PTPN1 | Tyr152 | ISEDIKSyYTVRQLE | dephosphorylation down-regulates activity | 11506178 | SIGNOR-248424 |
| PTPN1 | PTPN1 | Tyr153 | SEDIKSYyTVRQLEL | dephosphorylation down-regulates activity | 11506178 | SIGNOR-248425 |
| PTPN1 | PTPN1 | Tyr66 | LHQEDNDyINASLIK | dephosphorylation down-regulates activity | 11506178 | SIGNOR-248423 |
| PTPN1 | EPOR | – | dephosphorylation down-regulates activity | 14527337 | SIGNOR-276994 | |
| PTPN1 | NFKBIA | Tyr42 | DSMKDEEyEQMVKEL | dephosphorylation down-regulates | 8940099 | SIGNOR-45004 |
| PTPN1 | EPHA3 | Tyr779 | EDDPEAAyTTRGGKI | dephosphorylation down-regulates activity | 21135139 | SIGNOR-248426 |
| PTPN1 | TYK2 | – | dephosphorylation down-regulates activity | 15780598 | SIGNOR-134564 | |
| PTPN1 | AKT1 | – | dephosphorylation down-regulates | 15632081 | SIGNOR-252639 | |
| PTPN1 | CTNNB1 | – | dephosphorylation up-regulates activity | 12377785 | SIGNOR-277121 | |
| PTPN1 | IRS1 | – | dephosphorylation down-regulates | 10660596 | SIGNOR-74852 | |
| PTPN1 | KDR | Tyr1175 | AQQDGKDyIVLPISE | dephosphorylation down-regulates activity | 23639442 | SIGNOR-277011 |
| PTPN1 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates | 15821101 | SIGNOR-135211 |
| PTPN1 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 15821101 | SIGNOR-248427 |
| PTPN1 | STAT6 | – | dephosphorylation down-regulates activity | 22156494 | SIGNOR-277122 | |
| PTPN1 | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | dephosphorylation down-regulates activity | 10993888 | SIGNOR-248428 |
| PTPN1 | STAT5B | Tyr699 | TAKAVDGyVKPQIKQ | dephosphorylation down-regulates | 10993888 | SIGNOR-82042 |
| PTPN1 | STAT5B | Tyr699 | TAKAVDGyVKPQIKQ | dephosphorylation down-regulates activity | 10993888 | SIGNOR-248429 |
| PTPN1 | PITX1 | Tyr160 | LDLCKGGyVPQFSGL | dephosphorylation down-regulates quantity by destabilization | 27752061 | SIGNOR-276974 |
| PTPN1 | PITX1 | Tyr179 | EDVYAAGySYNNWAA | dephosphorylation down-regulates quantity by destabilization | 27752061 | SIGNOR-276973 |
| PTPN1 | CAV1 | Tyr14 | VDSEGHLyTVPIREQ | dephosphorylation unknown | 16388599 | SIGNOR-248430 |
| PTPN1 | PTK2 | – | dephosphorylation down-regulates | 16291744 | SIGNOR-141637 | |
| PTPN1 | PTK2 | Tyr397 | SVSETDDyAEIIDEE | dephosphorylation down-regulates activity | 16291744 | SIGNOR-248431 |
| PTPN1 | PRKCD | – | dephosphorylation down-regulates | 11350745 | SIGNOR-107754 | |
| PTPN1 | GAB1 | – | dephosphorylation down-regulates activity | 23521888 | SIGNOR-276965 | |
| PTPN1 | PTK6 | Tyr342 | RLIKEDVyLSHDHNI | dephosphorylation down-regulates activity | 29142193 | SIGNOR-277082 |
| PTPN1 | CTTN | Tyr446 | GTEPEPVySMEAADY | dephosphorylation up-regulates activity | 18387954 | SIGNOR-248432 |
| PTPN1 | CTTN | Tyr421 | RLPSSPVyEDAASFK | dephosphorylation up-regulates activity | 27824079 | SIGNOR-277027 |
| PTPN1 | MAPK14 | – | dephosphorylation down-regulates activity | 24590766 | SIGNOR-277167 | |
| PTPN1 | NTRK2 | Tyr706 | RDVYSTDyYRVGGHT | dephosphorylation down-regulates activity | 26214522 | SIGNOR-264554 |
| PTPN1 | NTRK2 | Tyr707 | DVYSTDYyRVGGHTM | dephosphorylation down-regulates activity | 26214522 | SIGNOR-264553 |
| PTPN1 | MAPK15 | Tyr177 | EDQAVTEyVATRWYR | dephosphorylation down-regulates | 16336213 | SIGNOR-142981 |
| PTPN1 | TRPV6 | – | dephosphorylation down-regulates | 17197020 | SIGNOR-151711 | |
| PTPN1 | TRPV6 | – | dephosphorylation down-regulates activity | 17197020 | SIGNOR-248433 | |
| PTPN1 | EIF2AK3 | – | dephosphorylation down-regulates activity | 22169477 | SIGNOR-277051 | |
| PTPN1 | AGO2 | Tyr393 | ASFNTDPyVREFGIM | dephosphorylation down-regulates activity | 25175024 | SIGNOR-277120 |
| PTPN1 | BCR-ABL | – | dephosphorylation down-regulates | 9566916 | SIGNOR-56822 | |
| PTPN1 | AKT | – | dephosphorylation down-regulates | 15632081 | SIGNOR-132959 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | dephosphorylation down-regulates ⊣ | JAK2 PTyr1008 | dephosphorylation up-regulates → | JAK2 | 15780598 | SIGNOR-133852 |
| PTPN1 | dephosphorylation down-regulates ⊣ | JAK2 PTyr1007 | dephosphorylation up-regulates → | JAK2 | 15821101 | SIGNOR-134955 |
| PTPN1 | dephosphorylation down-regulates ⊣ | JAK2 PTyr1007 | dephosphorylation up-regulates → | JAK2 | 11970898 | SIGNOR-248404 |
| PTPN1 | dephosphorylation down-regulates ⊣ | JAK2 PTyr1008 | dephosphorylation up-regulates → | JAK2 | 11970898 | SIGNOR-248405 |
| PTPN1 | dephosphorylation down-regulates ⊣ | STAM2 PTyr291 | dephosphorylation down-regulates ⊣ | STAM2 | 20504764 | SIGNOR-248406 |
| PTPN1 | dephosphorylation down-regulates ⊣ | EGFR PTyr1016 | dephosphorylation up-regulates → | EGFR | 8621392 | SIGNOR-248407 |
| PTPN1 | dephosphorylation down-regulates ⊣ | KRT8 PTyr267 | dephosphorylation up-regulates → | KRT8 | 24003221 | SIGNOR-265495 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 11579209 | SIGNOR-235495 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 11579209 | SIGNOR-235499 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 11579209 | SIGNOR-235503 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1185 | dephosphorylation up-regulates → | INSR | 16582879 | SIGNOR-248408 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 16582879 | SIGNOR-248409 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 16582879 | SIGNOR-248410 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1189 | dephosphorylation up-regulates → | INSR | 22124607 | SIGNOR-276947 |
| PTPN1 | dephosphorylation down-regulates ⊣ | INSR PTyr1190 | dephosphorylation up-regulates → | INSR | 22124607 | SIGNOR-276946 |
| PTPN1 | dephosphorylation down-regulates ⊣ | MET PTyr1234 | dephosphorylation up-regulates → | MET | 16537444 | SIGNOR-145141 |
| PTPN1 | dephosphorylation down-regulates ⊣ | MET PTyr1235 | dephosphorylation up-regulates → | MET | 16537444 | SIGNOR-145145 |
| PTPN1 | dephosphorylation down-regulates ⊣ | MET PTyr1234 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-181323 |
| PTPN1 | dephosphorylation down-regulates ⊣ | MET PTyr1235 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-181327 |
| PTPN1 | dephosphorylation down-regulates ⊣ | MET PTyr1234 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-248411 |
| PTPN1 | dephosphorylation down-regulates ⊣ | MET PTyr1235 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-248412 |
| PTPN1 | dephosphorylation down-regulates ⊣ | ROS1 PTyr2110 | dephosphorylation up-regulates → | ROS1 | 17416557 | SIGNOR-154199 |
| PTPN1 | dephosphorylation down-regulates ⊣ | ROS1 PTyr2114 | dephosphorylation up-regulates → | ROS1 | 17416557 | SIGNOR-154203 |
| PTPN1 | dephosphorylation down-regulates ⊣ | ROS1 PTyr2115 | dephosphorylation up-regulates → | ROS1 | 17416557 | SIGNOR-154207 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr1009 | dephosphorylation up-regulates → | PDGFRB | 18567737 | SIGNOR-179064 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr1021 | dephosphorylation up-regulates → | PDGFRB | 18567737 | SIGNOR-179068 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr716 | dephosphorylation up-regulates → | PDGFRB | 18567737 | SIGNOR-179072 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr751 | dephosphorylation up-regulates → | PDGFRB | 18567737 | SIGNOR-179076 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr771 | dephosphorylation up-regulates → | PDGFRB | 18567737 | SIGNOR-179080 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr1009 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248416 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr1021 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248417 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr740 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248413 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr751 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248414 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr771 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248415 |
| PTPN1 | dephosphorylation down-regulates ⊣ | GHR PTyr332 | dephosphorylation up-regulates → | GHR | 12907755 | SIGNOR-248418 |
| PTPN1 | dephosphorylation down-regulates ⊣ | GHR PTyr487 | dephosphorylation up-regulates → | GHR | 12907755 | SIGNOR-248419 |
| PTPN1 | dephosphorylation down-regulates ⊣ | GHR PTyr534 | dephosphorylation up-regulates → | GHR | 12907755 | SIGNOR-248420 |
| PTPN1 | dephosphorylation down-regulates ⊣ | GHR PTyr566 | dephosphorylation up-regulates → | GHR | 12907755 | SIGNOR-248421 |
| PTPN1 | dephosphorylation down-regulates ⊣ | ACTN1 PTyr12 | dephosphorylation up-regulates → | ACTN1 | 16291744 | SIGNOR-270539 |
| PTPN1 | dephosphorylation down-regulates ⊣ | ACTN1 PTyr12 | dephosphorylation down-regulates ⊣ | ACTN1 | 16291744 | SIGNOR-141634 |
| PTPN1 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 12857726 | SIGNOR-103607 |
| PTPN1 | dephosphorylation down-regulates ⊣ | SRC PTyr419 | dephosphorylation down-regulates ⊣ | SRC | 11007774 | SIGNOR-245299 |
| PTPN1 | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 17974954 | SIGNOR-248422 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PTPN1 PTyr152 | dephosphorylation up-regulates → | PTPN1 | 11506178 | SIGNOR-248424 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PTPN1 PTyr153 | dephosphorylation up-regulates → | PTPN1 | 11506178 | SIGNOR-248425 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PTPN1 PTyr66 | dephosphorylation up-regulates → | PTPN1 | 11506178 | SIGNOR-248423 |
| PTPN1 | dephosphorylation down-regulates ⊣ | NFKBIA PTyr42 | dephosphorylation up-regulates → | NFKBIA | 8940099 | SIGNOR-45004 |
| PTPN1 | dephosphorylation down-regulates ⊣ | EPHA3 PTyr779 | dephosphorylation up-regulates → | EPHA3 | 21135139 | SIGNOR-248426 |
| PTPN1 | dephosphorylation down-regulates ⊣ | KDR PTyr1175 | dephosphorylation up-regulates → | KDR | 23639442 | SIGNOR-277011 |
| PTPN1 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 15821101 | SIGNOR-135211 |
| PTPN1 | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 15821101 | SIGNOR-248427 |
| PTPN1 | dephosphorylation down-regulates ⊣ | STAT5A PTyr694 | dephosphorylation up-regulates → | STAT5A | 10993888 | SIGNOR-248428 |
| PTPN1 | dephosphorylation down-regulates ⊣ | STAT5B PTyr699 | dephosphorylation up-regulates → | STAT5B | 10993888 | SIGNOR-82042 |
| PTPN1 | dephosphorylation down-regulates ⊣ | STAT5B PTyr699 | dephosphorylation up-regulates → | STAT5B | 10993888 | SIGNOR-248429 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PITX1 PTyr160 | dephosphorylation up-regulates → | PITX1 | 27752061 | SIGNOR-276974 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PITX1 PTyr179 | dephosphorylation up-regulates → | PITX1 | 27752061 | SIGNOR-276973 |
| PTPN1 | dephosphorylation down-regulates ⊣ | CAV1 PTyr14 | dephosphorylation up-regulates → | CAV1 | 16388599 | SIGNOR-248430 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PTK2 PTyr397 | dephosphorylation up-regulates → | PTK2 | 16291744 | SIGNOR-248431 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PTK6 PTyr342 | dephosphorylation up-regulates → | PTK6 | 29142193 | SIGNOR-277082 |
| PTPN1 | dephosphorylation down-regulates ⊣ | CTTN PTyr446 | dephosphorylation down-regulates ⊣ | CTTN | 18387954 | SIGNOR-248432 |
| PTPN1 | dephosphorylation down-regulates ⊣ | CTTN PTyr421 | dephosphorylation down-regulates ⊣ | CTTN | 27824079 | SIGNOR-277027 |
| PTPN1 | dephosphorylation down-regulates ⊣ | NTRK2 PTyr706 | dephosphorylation up-regulates → | NTRK2 | 26214522 | SIGNOR-264554 |
| PTPN1 | dephosphorylation down-regulates ⊣ | NTRK2 PTyr707 | dephosphorylation up-regulates → | NTRK2 | 26214522 | SIGNOR-264553 |
| PTPN1 | dephosphorylation down-regulates ⊣ | MAPK15 PTyr177 | dephosphorylation up-regulates → | MAPK15 | 16336213 | SIGNOR-142981 |
| PTPN1 | dephosphorylation down-regulates ⊣ | AGO2 PTyr393 | dephosphorylation up-regulates → | AGO2 | 25175024 | SIGNOR-277120 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN1 | dephosphorylation down-regulates | LAT | SIGNOR-103599 |
| PTPN1 | dephosphorylation → down-regulates activity | LAT | SIGNOR-248403 |
| PTPN1 | dephosphorylation down-regulates | JAK2 | SIGNOR-133852 |
| PTPN1 | dephosphorylation down-regulates | JAK2 | SIGNOR-134955 |
| PTPN1 | dephosphorylation down-regulates | JAK2 | SIGNOR-135207 |
| PTPN1 | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-248404 |
| PTPN1 | dephosphorylation → down-regulates activity | JAK2 | SIGNOR-248405 |
| PTPN1 | dephosphorylation → up-regulates quantity by stabilization | STAM2 | SIGNOR-248406 |
| PTPN1 | dephosphorylation down-regulates | ABL1 | SIGNOR-56815 |
| PTPN1 | dephosphorylation → down-regulates activity | EGFR | SIGNOR-276981 |
| PTPN1 | dephosphorylation → down-regulates activity | EGFR | SIGNOR-248407 |
| PTPN1 | dephosphorylation → down-regulates activity | NTRK1 | SIGNOR-277081 |
| PTPN1 | dephosphorylation → down-regulates activity | KRT8 | SIGNOR-265495 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-235495 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-235499 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-235503 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-248408 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-248409 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-248410 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-276947 |
| PTPN1 | dephosphorylation → down-regulates activity | INSR | SIGNOR-276946 |
| PTPN1 | dephosphorylation → down-regulates activity | IGF1R | SIGNOR-115709 |
| PTPN1 | dephosphorylation down-regulates | MET | SIGNOR-145141 |
| PTPN1 | dephosphorylation down-regulates | MET | SIGNOR-145145 |
| PTPN1 | dephosphorylation down-regulates | MET | SIGNOR-181323 |
| PTPN1 | dephosphorylation down-regulates | MET | SIGNOR-181327 |
| PTPN1 | dephosphorylation → down-regulates activity | MET | SIGNOR-248411 |
| PTPN1 | dephosphorylation → down-regulates activity | MET | SIGNOR-248412 |
| PTPN1 | dephosphorylation → down-regulates activity | MET | SIGNOR-277001 |
| PTPN1 | dephosphorylation down-regulates | ROS1 | SIGNOR-154199 |
| PTPN1 | dephosphorylation down-regulates | ROS1 | SIGNOR-154203 |
| PTPN1 | dephosphorylation down-regulates | ROS1 | SIGNOR-154207 |
| PTPN1 | dephosphorylation down-regulates | PDGFRB | SIGNOR-179064 |
| PTPN1 | dephosphorylation down-regulates | PDGFRB | SIGNOR-179068 |
| PTPN1 | dephosphorylation down-regulates | PDGFRB | SIGNOR-179072 |
| PTPN1 | dephosphorylation down-regulates | PDGFRB | SIGNOR-179076 |
| PTPN1 | dephosphorylation down-regulates | PDGFRB | SIGNOR-179080 |
| PTPN1 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248416 |
| PTPN1 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248417 |
| PTPN1 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248413 |
| PTPN1 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248414 |
| PTPN1 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248415 |
| PTPN1 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248418 |
| PTPN1 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248419 |
| PTPN1 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248420 |
| PTPN1 | dephosphorylation → down-regulates activity | GHR | SIGNOR-248421 |
| PTPN1 | dephosphorylation down-regulates | BCR | SIGNOR-56818 |
| PTPN1 | dephosphorylation → down-regulates activity | ACTN1 | SIGNOR-270539 |
| PTPN1 | dephosphorylation → up-regulates | ACTN1 | SIGNOR-141634 |
| PTPN1 | dephosphorylation → up-regulates | SRC | SIGNOR-103607 |
| PTPN1 | dephosphorylation → up-regulates activity | SRC | SIGNOR-245299 |
| PTPN1 | dephosphorylation → up-regulates activity | SRC | SIGNOR-248422 |
| PTPN1 | dephosphorylation → down-regulates activity | PTPN1 | SIGNOR-248424 |
| PTPN1 | dephosphorylation → down-regulates activity | PTPN1 | SIGNOR-248425 |
| PTPN1 | dephosphorylation → down-regulates activity | PTPN1 | SIGNOR-248423 |
| PTPN1 | dephosphorylation → down-regulates activity | EPOR | SIGNOR-276994 |
| PTPN1 | dephosphorylation down-regulates | NFKBIA | SIGNOR-45004 |
| PTPN1 | dephosphorylation → down-regulates activity | EPHA3 | SIGNOR-248426 |
| PTPN1 | dephosphorylation → down-regulates activity | TYK2 | SIGNOR-134564 |
| PTPN1 | dephosphorylation down-regulates | AKT1 | SIGNOR-252639 |
| PTPN1 | dephosphorylation → up-regulates activity | CTNNB1 | SIGNOR-277121 |
| PTPN1 | dephosphorylation down-regulates | IRS1 | SIGNOR-74852 |
| PTPN1 | dephosphorylation → down-regulates activity | KDR | SIGNOR-277011 |
| PTPN1 | dephosphorylation down-regulates | STAT3 | SIGNOR-135211 |
| PTPN1 | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-248427 |
| PTPN1 | dephosphorylation → down-regulates activity | STAT6 | SIGNOR-277122 |
| PTPN1 | dephosphorylation → down-regulates activity | STAT5A | SIGNOR-248428 |
| PTPN1 | dephosphorylation down-regulates | STAT5B | SIGNOR-82042 |
| PTPN1 | dephosphorylation → down-regulates activity | STAT5B | SIGNOR-248429 |
| PTPN1 | dephosphorylation down-regulates quantity by destabilization | PITX1 | SIGNOR-276974 |
| PTPN1 | dephosphorylation down-regulates quantity by destabilization | PITX1 | SIGNOR-276973 |
| PTPN1 | dephosphorylation → unknown | CAV1 | SIGNOR-248430 |
| PTPN1 | dephosphorylation down-regulates | PTK2 | SIGNOR-141637 |
| PTPN1 | dephosphorylation → down-regulates activity | PTK2 | SIGNOR-248431 |
| PTPN1 | dephosphorylation down-regulates | PRKCD | SIGNOR-107754 |
| PTPN1 | dephosphorylation → down-regulates activity | GAB1 | SIGNOR-276965 |
| PTPN1 | dephosphorylation → down-regulates activity | PTK6 | SIGNOR-277082 |
| PTPN1 | dephosphorylation → up-regulates activity | CTTN | SIGNOR-248432 |
| PTPN1 | dephosphorylation → up-regulates activity | CTTN | SIGNOR-277027 |
| PTPN1 | dephosphorylation → down-regulates activity | MAPK14 | SIGNOR-277167 |
| PTPN1 | dephosphorylation → down-regulates activity | NTRK2 | SIGNOR-264554 |
| PTPN1 | dephosphorylation → down-regulates activity | NTRK2 | SIGNOR-264553 |
| PTPN1 | dephosphorylation down-regulates | MAPK15 | SIGNOR-142981 |
| PTPN1 | dephosphorylation down-regulates | TRPV6 | SIGNOR-151711 |
| PTPN1 | dephosphorylation → down-regulates activity | TRPV6 | SIGNOR-248433 |
| PTPN1 | dephosphorylation → down-regulates activity | EIF2AK3 | SIGNOR-277051 |
| PTPN1 | dephosphorylation → down-regulates activity | AGO2 | SIGNOR-277120 |
| PTPN1 | dephosphorylation down-regulates | BCR-ABL | SIGNOR-56822 |
| PTPN1 | dephosphorylation down-regulates | AKT | SIGNOR-132959 |