| Name | PTPN1 |
| ID | P18031 |
| Role | substrate |
| Enzymatic Domains |
Tyrosine-protein phosphatase 3-277 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| INSR | PTPN1 | Tyr152 | ISEDIKSyYTVRQLE | phosphorylation up-regulates activity | 11506178 | SIGNOR-249368 |
| CLK1 | PTPN1 | Ser242 | MDKRKDPsSVDIKKV | phosphorylation up-regulates activity | 10480872 | SIGNOR-250773 |
| PTPN1 | PTPN1 | Tyr152 | ISEDIKSyYTVRQLE | dephosphorylation down-regulates activity | 11506178 | SIGNOR-248424 |
| CyclinB/CDK1 | PTPN1 | Ser386 | LRGAQAAsPAKGEPS | phosphorylation up-regulates activity | 23348582 | SIGNOR-272971 |
| PTPN1 | PTPN1 | Tyr153 | SEDIKSYyTVRQLEL | dephosphorylation down-regulates activity | 11506178 | SIGNOR-248425 |
| EGFR | PTPN1 | Tyr66 | LHQEDNDyINASLIK | phosphorylation up-regulates | 9355745 | SIGNOR-52950 |
| INSR | PTPN1 | Tyr66 | LHQEDNDyINASLIK | phosphorylation up-regulates activity | 11506178 | SIGNOR-249370 |
| CSNK2A2 | PTPN1 | – | phosphorylation unknown | 9600099 | SIGNOR-251028 | |
| CLK2 | PTPN1 | Ser242 | MDKRKDPsSVDIKKV | phosphorylation up-regulates activity | 10480872 | SIGNOR-250775 |
| CDK1 | PTPN1 | Ser386 | LRGAQAAsPAKGEPS | phosphorylation unknown | 8491187 | SIGNOR-39233 |
| GSK3B | PTPN1 | – | phosphorylation down-regulates quantity | 21554241 | SIGNOR-279724 | |
| AKT2 | PTPN1 | Ser50 | RNRYRDVsPFDHSRI | phosphorylation down-regulates activity | 11579209 | SIGNOR-235491 |
| AKT1 | PTPN1 | Ser50 | RNRYRDVsPFDHSRI | phosphorylation down-regulates activity | 11579209 | SIGNOR-252542 |
| CLK1 | PTPN1 | Ser243 | DKRKDPSsVDIKKVL | phosphorylation up-regulates activity | 10480872 | SIGNOR-250774 |
| PRKCA | PTPN1 | – | phosphorylation up-regulates activity | 22031842 | SIGNOR-279257 | |
| CLK1 | PTPN1 | Ser50 | RNRYRDVsPFDHSRI | phosphorylation up-regulates activity | 10480872 | SIGNOR-70563 |
| AKT | PTPN1 | Ser50 | RNRYRDVsPFDHSRI | phosphorylation down-regulates activity | 11579209 | SIGNOR-235411 |
| PTPN1 | PTPN1 | Tyr66 | LHQEDNDyINASLIK | dephosphorylation down-regulates activity | 11506178 | SIGNOR-248423 |
| CLK2 | PTPN1 | Ser50 | RNRYRDVsPFDHSRI | phosphorylation up-regulates activity | 10480872 | SIGNOR-70603 |
| CSNK2A1 | PTPN1 | – | phosphorylation unknown | 9600099 | SIGNOR-250941 | |
| INSR | PTPN1 | Tyr153 | SEDIKSYyTVRQLEL | phosphorylation up-regulates activity | 11506178 | SIGNOR-249369 |
| CDK1 | PTPN1 | Ser386 | LRGAQAAsPAKGEPS | phosphorylation up-regulates activity | 23348582 | SIGNOR-272970 |
| PLK1 | PTPN1 | Ser286 | KFIMGDSsVQDQWKE | phosphorylation up-regulates activity | 23348582 | SIGNOR-272990 |
| CLK2 | PTPN1 | Ser243 | DKRKDPSsVDIKKVL | phosphorylation up-regulates activity | 10480872 | SIGNOR-250776 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| INSR | phosphorylation up-regulates → | PTPN1 PTyr152 | phosphorylation up-regulates → | PTPN1 | 11506178 | SIGNOR-249368 |
| CLK1 | phosphorylation up-regulates → | PTPN1 PSer242 | phosphorylation up-regulates → | PTPN1 | 10480872 | SIGNOR-250773 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PTPN1 PTyr152 | dephosphorylation up-regulates → | PTPN1 | 11506178 | SIGNOR-248424 |
| CyclinB/CDK1 | phosphorylation up-regulates → | PTPN1 PSer386 | phosphorylation up-regulates → | PTPN1 | 23348582 | SIGNOR-272971 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PTPN1 PTyr153 | dephosphorylation up-regulates → | PTPN1 | 11506178 | SIGNOR-248425 |
| EGFR | phosphorylation up-regulates → | PTPN1 PTyr66 | phosphorylation up-regulates → | PTPN1 | 9355745 | SIGNOR-52950 |
| INSR | phosphorylation up-regulates → | PTPN1 PTyr66 | phosphorylation up-regulates → | PTPN1 | 11506178 | SIGNOR-249370 |
| CLK2 | phosphorylation up-regulates → | PTPN1 PSer242 | phosphorylation up-regulates → | PTPN1 | 10480872 | SIGNOR-250775 |
| CDK1 | phosphorylation up-regulates → | PTPN1 PSer386 | phosphorylation down-regulates ⊣ | PTPN1 | 8491187 | SIGNOR-39233 |
| AKT2 | phosphorylation up-regulates → | PTPN1 PSer50 | phosphorylation down-regulates ⊣ | PTPN1 | 11579209 | SIGNOR-235491 |
| AKT1 | phosphorylation up-regulates → | PTPN1 PSer50 | phosphorylation down-regulates ⊣ | PTPN1 | 11579209 | SIGNOR-252542 |
| CLK1 | phosphorylation up-regulates → | PTPN1 PSer243 | phosphorylation up-regulates → | PTPN1 | 10480872 | SIGNOR-250774 |
| CLK1 | phosphorylation up-regulates → | PTPN1 PSer50 | phosphorylation up-regulates → | PTPN1 | 10480872 | SIGNOR-70563 |
| AKT | phosphorylation up-regulates → | PTPN1 PSer50 | phosphorylation down-regulates ⊣ | PTPN1 | 11579209 | SIGNOR-235411 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PTPN1 PTyr66 | dephosphorylation up-regulates → | PTPN1 | 11506178 | SIGNOR-248423 |
| CLK2 | phosphorylation up-regulates → | PTPN1 PSer50 | phosphorylation up-regulates → | PTPN1 | 10480872 | SIGNOR-70603 |
| INSR | phosphorylation up-regulates → | PTPN1 PTyr153 | phosphorylation up-regulates → | PTPN1 | 11506178 | SIGNOR-249369 |
| CDK1 | phosphorylation up-regulates → | PTPN1 PSer386 | phosphorylation up-regulates → | PTPN1 | 23348582 | SIGNOR-272970 |
| PLK1 | phosphorylation up-regulates → | PTPN1 PSer286 | phosphorylation up-regulates → | PTPN1 | 23348582 | SIGNOR-272990 |
| CLK2 | phosphorylation up-regulates → | PTPN1 PSer243 | phosphorylation up-regulates → | PTPN1 | 10480872 | SIGNOR-250776 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| INSR | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-249368 |
| CLK1 | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-250773 |
| PTPN1 | dephosphorylation → down-regulates activity | PTPN1 | SIGNOR-248424 |
| CyclinB/CDK1 | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-272971 |
| PTPN1 | dephosphorylation → down-regulates activity | PTPN1 | SIGNOR-248425 |
| EGFR | phosphorylation → up-regulates | PTPN1 | SIGNOR-52950 |
| INSR | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-249370 |
| CSNK2A2 | phosphorylation → unknown | PTPN1 | SIGNOR-251028 |
| CLK2 | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-250775 |
| CDK1 | phosphorylation → unknown | PTPN1 | SIGNOR-39233 |
| GSK3B | phosphorylation → down-regulates quantity | PTPN1 | SIGNOR-279724 |
| AKT2 | phosphorylation → down-regulates activity | PTPN1 | SIGNOR-235491 |
| AKT1 | phosphorylation → down-regulates activity | PTPN1 | SIGNOR-252542 |
| CLK1 | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-250774 |
| PRKCA | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-279257 |
| CLK1 | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-70563 |
| AKT | phosphorylation → down-regulates activity | PTPN1 | SIGNOR-235411 |
| PTPN1 | dephosphorylation → down-regulates activity | PTPN1 | SIGNOR-248423 |
| CLK2 | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-70603 |
| CSNK2A1 | phosphorylation → unknown | PTPN1 | SIGNOR-250941 |
| INSR | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-249369 |
| CDK1 | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-272970 |
| PLK1 | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-272990 |
| CLK2 | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-250776 |