Entity Details

Name AKT1_Ser50
ID P18031
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
AKT2PTPN1Ser50RNRYRDVsPFDHSRIphosphorylation
down-regulates activity		11579209SIGNOR-235491
AKTPTPN1Ser50RNRYRDVsPFDHSRIphosphorylation
down-regulates activity		11579209SIGNOR-235411
CLK1PTPN1Ser50RNRYRDVsPFDHSRIphosphorylation
up-regulates activity		10480872SIGNOR-70563
AKT1PTPN1Ser50RNRYRDVsPFDHSRIphosphorylation
down-regulates activity		11579209SIGNOR-252542
CLK2PTPN1Ser50RNRYRDVsPFDHSRIphosphorylation
up-regulates activity		10480872SIGNOR-70603
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
AKT2phosphorylation
up-regulates
→
PTPN1
PSer50		phosphorylation
down-regulates
⊣		PTPN111579209SIGNOR-235491
AKTphosphorylation
up-regulates
→
PTPN1
PSer50		phosphorylation
down-regulates
⊣		PTPN111579209SIGNOR-235411
CLK1phosphorylation
up-regulates
→
PTPN1
PSer50		phosphorylation
up-regulates
→		PTPN110480872SIGNOR-70563
AKT1phosphorylation
up-regulates
→
PTPN1
PSer50		phosphorylation
down-regulates
⊣		PTPN111579209SIGNOR-252542
CLK2phosphorylation
up-regulates
→
PTPN1
PSer50		phosphorylation
up-regulates
→		PTPN110480872SIGNOR-70603
Regulator Mechanism/Effect Target SIGNOR-ID
AKT2phosphorylation
→
down-regulates activity 		PTPN1SIGNOR-235491
AKTphosphorylation
→
down-regulates activity 		PTPN1SIGNOR-235411
CLK1phosphorylation
→
up-regulates activity 		PTPN1SIGNOR-70563
AKT1phosphorylation
→
down-regulates activity 		PTPN1SIGNOR-252542
CLK2phosphorylation
→
up-regulates activity 		PTPN1SIGNOR-70603