| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CLK1 | PTPN1 | Ser243 | DKRKDPSsVDIKKVL | phosphorylation up-regulates activity | 10480872 | SIGNOR-250774 |
| CLK2 | PTPN1 | Ser243 | DKRKDPSsVDIKKVL | phosphorylation up-regulates activity | 10480872 | SIGNOR-250776 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CLK1 | phosphorylation up-regulates → | PTPN1 PSer243 | phosphorylation up-regulates → | PTPN1 | 10480872 | SIGNOR-250774 |
| CLK2 | phosphorylation up-regulates → | PTPN1 PSer243 | phosphorylation up-regulates → | PTPN1 | 10480872 | SIGNOR-250776 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CLK1 | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-250774 |
| CLK2 | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-250776 |