Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
AKT2	PTPN1	Ser50 View in OncoXplorer	RNRYRDVsPFDHSRI	phosphorylation down-regulates activity	11579209	SIGNOR-235491
AKT1	PTPN1	Ser50 View in OncoXplorer	RNRYRDVsPFDHSRI	phosphorylation down-regulates activity	11579209	SIGNOR-252542
CLK1	PTPN1	Ser50 View in OncoXplorer	RNRYRDVsPFDHSRI	phosphorylation up-regulates activity	10480872	SIGNOR-70563
AKT	PTPN1	Ser50 View in OncoXplorer	RNRYRDVsPFDHSRI	phosphorylation down-regulates activity	11579209	SIGNOR-235411
CLK2	PTPN1	Ser50 View in OncoXplorer	RNRYRDVsPFDHSRI	phosphorylation up-regulates activity	10480872	SIGNOR-70603

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
AKT2	phosphorylation up-regulates →	PTPN1 PSer50	phosphorylation down-regulates ⊣	PTPN1	11579209	SIGNOR-235491
AKT1	phosphorylation up-regulates →	PTPN1 PSer50	phosphorylation down-regulates ⊣	PTPN1	11579209	SIGNOR-252542
CLK1	phosphorylation up-regulates →	PTPN1 PSer50	phosphorylation up-regulates →	PTPN1	10480872	SIGNOR-70563
AKT	phosphorylation up-regulates →	PTPN1 PSer50	phosphorylation down-regulates ⊣	PTPN1	11579209	SIGNOR-235411
CLK2	phosphorylation up-regulates →	PTPN1 PSer50	phosphorylation up-regulates →	PTPN1	10480872	SIGNOR-70603

Regulator	Mechanism/Effect	Target	SIGNOR-ID
AKT2	phosphorylation → down-regulates activity	PTPN1	SIGNOR-235491
AKT1	phosphorylation → down-regulates activity	PTPN1	SIGNOR-252542
CLK1	phosphorylation → up-regulates activity	PTPN1	SIGNOR-70563
AKT	phosphorylation → down-regulates activity	PTPN1	SIGNOR-235411
CLK2	phosphorylation → up-regulates activity	PTPN1	SIGNOR-70603