| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | PTPN1 | Ser386 | LRGAQAAsPAKGEPS | phosphorylation up-regulates activity | 23348582 | SIGNOR-272971 |
| CDK1 | PTPN1 | Ser386 | LRGAQAAsPAKGEPS | phosphorylation up-regulates activity | 23348582 | SIGNOR-272970 |
| CDK1 | PTPN1 | Ser386 | LRGAQAAsPAKGEPS | phosphorylation unknown | 8491187 | SIGNOR-39233 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | phosphorylation up-regulates → | PTPN1 PSer386 | phosphorylation up-regulates → | PTPN1 | 23348582 | SIGNOR-272971 |
| CDK1 | phosphorylation up-regulates → | PTPN1 PSer386 | phosphorylation up-regulates → | PTPN1 | 23348582 | SIGNOR-272970 |
| CDK1 | phosphorylation up-regulates → | PTPN1 PSer386 | phosphorylation down-regulates ⊣ | PTPN1 | 8491187 | SIGNOR-39233 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinB/CDK1 | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-272971 |
| CDK1 | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-272970 |
| CDK1 | phosphorylation → unknown | PTPN1 | SIGNOR-39233 |
