| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | PTPN1 | Tyr66 | LHQEDNDyINASLIK | dephosphorylation down-regulates activity | 11506178 | SIGNOR-248423 |
| EGFR | PTPN1 | Tyr66 | LHQEDNDyINASLIK | phosphorylation up-regulates | 9355745 | SIGNOR-52950 |
| INSR | PTPN1 | Tyr66 | LHQEDNDyINASLIK | phosphorylation up-regulates activity | 11506178 | SIGNOR-249370 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | dephosphorylation down-regulates ⊣ | PTPN1 PTyr66 | dephosphorylation up-regulates → | PTPN1 | 11506178 | SIGNOR-248423 |
| EGFR | phosphorylation up-regulates → | PTPN1 PTyr66 | phosphorylation up-regulates → | PTPN1 | 9355745 | SIGNOR-52950 |
| INSR | phosphorylation up-regulates → | PTPN1 PTyr66 | phosphorylation up-regulates → | PTPN1 | 11506178 | SIGNOR-249370 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN1 | dephosphorylation → down-regulates activity | PTPN1 | SIGNOR-248423 |
| EGFR | phosphorylation → up-regulates | PTPN1 | SIGNOR-52950 |
| INSR | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-249370 |
