| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CLK1 | PTPN1 | Ser50 | RNRYRDVsPFDHSRI | phosphorylation up-regulates activity | 10480872 | SIGNOR-70563 |
| AKT1 | PTPN1 | Ser50 | RNRYRDVsPFDHSRI | phosphorylation down-regulates activity | 11579209 | SIGNOR-252542 |
| CLK2 | PTPN1 | Ser50 | RNRYRDVsPFDHSRI | phosphorylation up-regulates activity | 10480872 | SIGNOR-70603 |
| AKT | PTPN1 | Ser50 | RNRYRDVsPFDHSRI | phosphorylation down-regulates activity | 11579209 | SIGNOR-235411 |
| AKT2 | PTPN1 | Ser50 | RNRYRDVsPFDHSRI | phosphorylation down-regulates activity | 11579209 | SIGNOR-235491 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CLK1 | phosphorylation up-regulates → | PTPN1 PSer50 | phosphorylation up-regulates → | PTPN1 | 10480872 | SIGNOR-70563 |
| AKT1 | phosphorylation up-regulates → | PTPN1 PSer50 | phosphorylation down-regulates ⊣ | PTPN1 | 11579209 | SIGNOR-252542 |
| CLK2 | phosphorylation up-regulates → | PTPN1 PSer50 | phosphorylation up-regulates → | PTPN1 | 10480872 | SIGNOR-70603 |
| AKT | phosphorylation up-regulates → | PTPN1 PSer50 | phosphorylation down-regulates ⊣ | PTPN1 | 11579209 | SIGNOR-235411 |
| AKT2 | phosphorylation up-regulates → | PTPN1 PSer50 | phosphorylation down-regulates ⊣ | PTPN1 | 11579209 | SIGNOR-235491 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CLK1 | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-70563 |
| AKT1 | phosphorylation → down-regulates activity | PTPN1 | SIGNOR-252542 |
| CLK2 | phosphorylation → up-regulates activity | PTPN1 | SIGNOR-70603 |
| AKT | phosphorylation → down-regulates activity | PTPN1 | SIGNOR-235411 |
| AKT2 | phosphorylation → down-regulates activity | PTPN1 | SIGNOR-235491 |
