| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | VCL | Tyr822 | KSFLDSGyRILGAVA | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254731 |
| ABL1 | VCL | Tyr822 | KSFLDSGyRILGAVA | phosphorylation up-regulates activity | 24751539 | SIGNOR-278464 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | dephosphorylation down-regulates ⊣ | VCL PTyr822 | dephosphorylation up-regulates → | VCL | 25624455 | SIGNOR-254731 |
| ABL1 | phosphorylation up-regulates → | VCL PTyr822 | phosphorylation up-regulates → | VCL | 24751539 | SIGNOR-278464 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRG | dephosphorylation → down-regulates activity | VCL | SIGNOR-254731 |
| ABL1 | phosphorylation → up-regulates activity | VCL | SIGNOR-278464 |
