| Name | PTPRA |
| ID | P18433 |
| Role | phosphatase |
| Enzymatic Domains |
Tyrosine-protein phosphatase 1 241-501 PROSITE-ProRule
Tyrosine-protein phosphatase 2 533-791 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRA | FYN | Tyr531 | FTATEPQyQPGENL | dephosphorylation up-regulates | 17507376 | SIGNOR-154796 |
| PTPRA | FYN | Tyr531 | FTATEPQyQPGENL | dephosphorylation up-regulates activity | 9535845 | SIGNOR-248435 |
| PTPRA | LYN | Tyr397 | RVIEDNEyTAREGAK | dephosphorylation down-regulates activity | 15537644 | SIGNOR-248436 |
| PTPRA | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates | 7691597 | SIGNOR-32014 |
| PTPRA | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 10698938 | SIGNOR-248438 |
| PTPRA | SRC | Tyr530 | FTSTEPQyQPGENL | dephosphorylation up-regulates activity | 17974954 | SIGNOR-248437 |
| PTPRA | PTPRA | Tyr798 | YIDAFSDyANFK | dephosphorylation down-regulates activity | 7518772 | SIGNOR-248439 |
| PTPRA | KCNB1 | – | dephosphorylation down-regulates | 16870705 | SIGNOR-148301 | |
| PTPRA | VPS33B | – | dephosphorylation down-regulates activity | 18474358 | SIGNOR-277015 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRA | dephosphorylation down-regulates ⊣ | FYN PTyr531 | dephosphorylation down-regulates ⊣ | FYN | 17507376 | SIGNOR-154796 |
| PTPRA | dephosphorylation down-regulates ⊣ | FYN PTyr531 | dephosphorylation down-regulates ⊣ | FYN | 9535845 | SIGNOR-248435 |
| PTPRA | dephosphorylation down-regulates ⊣ | LYN PTyr397 | dephosphorylation up-regulates → | LYN | 15537644 | SIGNOR-248436 |
| PTPRA | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 7691597 | SIGNOR-32014 |
| PTPRA | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 10698938 | SIGNOR-248438 |
| PTPRA | dephosphorylation down-regulates ⊣ | SRC PTyr530 | dephosphorylation down-regulates ⊣ | SRC | 17974954 | SIGNOR-248437 |
| PTPRA | dephosphorylation down-regulates ⊣ | PTPRA PTyr798 | dephosphorylation up-regulates → | PTPRA | 7518772 | SIGNOR-248439 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRA | dephosphorylation → up-regulates | FYN | SIGNOR-154796 |
| PTPRA | dephosphorylation → up-regulates activity | FYN | SIGNOR-248435 |
| PTPRA | dephosphorylation → down-regulates activity | LYN | SIGNOR-248436 |
| PTPRA | dephosphorylation → up-regulates | SRC | SIGNOR-32014 |
| PTPRA | dephosphorylation → up-regulates activity | SRC | SIGNOR-248438 |
| PTPRA | dephosphorylation → up-regulates activity | SRC | SIGNOR-248437 |
| PTPRA | dephosphorylation → down-regulates activity | PTPRA | SIGNOR-248439 |
| PTPRA | dephosphorylation down-regulates | KCNB1 | SIGNOR-148301 |
| PTPRA | dephosphorylation → down-regulates activity | VPS33B | SIGNOR-277015 |