Entity Details

Name PTPRA
ID P18433
Role substrate
Enzymatic Domains
Tyrosine-protein phosphatase 1 241-501
PROSITE-ProRule
Tyrosine-protein phosphatase 2 533-791
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
SRCPTPRATyr798
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YIDAFSDyANFKphosphorylation
up-regulates activity		7518772SIGNOR-111306
PRKCDPTPRASer213PLLARSPsTNRKYPPphosphorylation
up-regulates activity		11676480SIGNOR-249114
PRKCDPTPRASer189
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QAGSHSNsFRLSNGRphosphorylation
up-regulates activity		11676480SIGNOR-249113
PTPRAPTPRATyr798
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YIDAFSDyANFKdephosphorylation
down-regulates activity		7518772SIGNOR-248439
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
SRCphosphorylation
up-regulates
→
PTPRA
PTyr798		phosphorylation
up-regulates
→		PTPRA7518772SIGNOR-111306
PRKCDphosphorylation
up-regulates
→
PTPRA
PSer213		phosphorylation
up-regulates
→		PTPRA11676480SIGNOR-249114
PRKCDphosphorylation
up-regulates
→
PTPRA
PSer189		phosphorylation
up-regulates
→		PTPRA11676480SIGNOR-249113
PTPRAdephosphorylation
down-regulates
⊣
PTPRA
PTyr798		dephosphorylation
up-regulates
→		PTPRA7518772SIGNOR-248439
Regulator Mechanism/Effect Target SIGNOR-ID
SRCphosphorylation
→
up-regulates activity 		PTPRASIGNOR-111306
PRKCDphosphorylation
→
up-regulates activity 		PTPRASIGNOR-249114
PRKCDphosphorylation
→
up-regulates activity 		PTPRASIGNOR-249113
PTPRAdephosphorylation
→
down-regulates activity 		PTPRASIGNOR-248439