| Name | ATF4 |
| ID | P18848 |
| Role | substrate |
| Enzymatic Domains |
bZIP 278-341 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RET | ATF4 | Thr115 | MPDDLLTtLDDTCDL | phosphorylation down-regulates quantity by destabilization | 25795775 | SIGNOR-276447 |
| RET | ATF4 | Thr119 | LLTTLDDtCDLFAPL | phosphorylation down-regulates quantity by destabilization | 25795775 | SIGNOR-276450 |
| CSNK2B | ATF4 | Ser215 | IKEEDTPsDNDSGIC | phosphorylation down-regulates quantity by destabilization | 23123191 | SIGNOR-276424 |
| RPS6KA3 | ATF4 | Ser245 | TRGSPNRsLPSPGVL | phosphorylation up-regulates | 15109498 | SIGNOR-124436 |
| RET | ATF4 | – | phosphorylation down-regulates activity | 25795775 | SIGNOR-280103 | |
| RET | ATF4 | Thr107 | LGIDDLEtMPDDLLT | phosphorylation down-regulates quantity by destabilization | 25795775 | SIGNOR-276448 |
| RET | ATF4 | Thr114 | TMPDDLLtTLDDTCD | phosphorylation down-regulates quantity by destabilization | 25795775 | SIGNOR-276449 |
| CSNK2A1 | ATF4 | Ser215 | IKEEDTPsDNDSGIC | phosphorylation down-regulates quantity by destabilization | 23123191 | SIGNOR-276425 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RET | phosphorylation up-regulates → | ATF4 PThr115 | phosphorylation down-regulates ⊣ | ATF4 | 25795775 | SIGNOR-276447 |
| RET | phosphorylation up-regulates → | ATF4 PThr119 | phosphorylation down-regulates ⊣ | ATF4 | 25795775 | SIGNOR-276450 |
| CSNK2B | phosphorylation up-regulates → | ATF4 PSer215 | phosphorylation down-regulates ⊣ | ATF4 | 23123191 | SIGNOR-276424 |
| RPS6KA3 | phosphorylation up-regulates → | ATF4 PSer245 | phosphorylation up-regulates → | ATF4 | 15109498 | SIGNOR-124436 |
| RET | phosphorylation up-regulates → | ATF4 PThr107 | phosphorylation down-regulates ⊣ | ATF4 | 25795775 | SIGNOR-276448 |
| RET | phosphorylation up-regulates → | ATF4 PThr114 | phosphorylation down-regulates ⊣ | ATF4 | 25795775 | SIGNOR-276449 |
| CSNK2A1 | phosphorylation up-regulates → | ATF4 PSer215 | phosphorylation down-regulates ⊣ | ATF4 | 23123191 | SIGNOR-276425 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RET | phosphorylation down-regulates quantity by destabilization | ATF4 | SIGNOR-276447 |
| RET | phosphorylation down-regulates quantity by destabilization | ATF4 | SIGNOR-276450 |
| CSNK2B | phosphorylation down-regulates quantity by destabilization | ATF4 | SIGNOR-276424 |
| RPS6KA3 | phosphorylation → up-regulates | ATF4 | SIGNOR-124436 |
| RET | phosphorylation → down-regulates activity | ATF4 | SIGNOR-280103 |
| RET | phosphorylation down-regulates quantity by destabilization | ATF4 | SIGNOR-276448 |
| RET | phosphorylation down-regulates quantity by destabilization | ATF4 | SIGNOR-276449 |
| CSNK2A1 | phosphorylation down-regulates quantity by destabilization | ATF4 | SIGNOR-276425 |