Entity Details

Name MYL12A
ID P19105
Role substrate
Enzymatic Domains
EF-hand 1 28-63
PROSITE-ProRule
EF-hand 2 97-132
PROSITE-ProRule
EF-hand 3 133-168
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ROCK1MYL12ASer19KRPQRATsNVFAMFDphosphorylation
up-regulates activity		12185584SIGNOR-263073
PAK2MYL12ASer19KRPQRATsNVFAMFDphosphorylation
up-regulates activity		10047984SIGNOR-263020
ROCK1MYL12AThr18
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KKRPQRAtSNVFAMFphosphorylation
up-regulates activity		12185584SIGNOR-263074
DAPK1MYL12ASer19KRPQRATsNVFAMFDphosphorylation
up-regulates activity		11485996SIGNOR-262842
DAPK1MYL12AThr18
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KKRPQRAtSNVFAMFphosphorylation
up-regulates activity		11485996SIGNOR-262843
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ROCK1phosphorylation
up-regulates
→
MYL12A
PSer19		phosphorylation
up-regulates
→		MYL12A12185584SIGNOR-263073
PAK2phosphorylation
up-regulates
→
MYL12A
PSer19		phosphorylation
up-regulates
→		MYL12A10047984SIGNOR-263020
ROCK1phosphorylation
up-regulates
→
MYL12A
PThr18		phosphorylation
up-regulates
→		MYL12A12185584SIGNOR-263074
DAPK1phosphorylation
up-regulates
→
MYL12A
PSer19		phosphorylation
up-regulates
→		MYL12A11485996SIGNOR-262842
DAPK1phosphorylation
up-regulates
→
MYL12A
PThr18		phosphorylation
up-regulates
→		MYL12A11485996SIGNOR-262843
Regulator Mechanism/Effect Target SIGNOR-ID
ROCK1phosphorylation
→
up-regulates activity 		MYL12ASIGNOR-263073
PAK2phosphorylation
→
up-regulates activity 		MYL12ASIGNOR-263020
ROCK1phosphorylation
→
up-regulates activity 		MYL12ASIGNOR-263074
DAPK1phosphorylation
→
up-regulates activity 		MYL12ASIGNOR-262842
DAPK1phosphorylation
→
up-regulates activity 		MYL12ASIGNOR-262843