| Name | PLCG1 |
| ID | P19174 |
| Role | substrate |
| Enzymatic Domains |
PH 1 27-142 PROSITE-ProRule
EF-hand 152-187 PROSITE-ProRule
PI-PLC X-box 320-464 PROSITE-ProRule
PH 2; first part 489-523 PROSITE-ProRule
SH2 1 550-657 PROSITE-ProRule
SH2 2 668-756 PROSITE-ProRule
SH3 791-851 PROSITE-ProRule
PH 2; second part 895-931 PROSITE-ProRule
PI-PLC Y-box 953-1070 PROSITE-ProRule
C2 1071-1194 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SYK | PLCG1 | Tyr771 | IGTAEPDyGALYEGR | phosphorylation up-regulates activity | 8657103 | SIGNOR-246572 |
| PTPRF | PLCG1 | – | dephosphorylation down-regulates | 11121408 | SIGNOR-85166 | |
| EPHA2 | PLCG1 | – | phosphorylation up-regulates activity | 32753469 | SIGNOR-279708 | |
| PRKACA | PLCG1 | Ser1248 | HGRAREGsFESRYQQ | phosphorylation down-regulates | 1370476 | SIGNOR-17901 |
| PTPRJ | PLCG1 | – | dephosphorylation down-regulates | 11259588 | SIGNOR-105790 | |
| NTRK2 | PLCG1 | – | phosphorylation up-regulates activity | 20445044 | SIGNOR-279241 | |
| SYK | PLCG1 | Tyr783 | EGRNPGFyVEANPMP | phosphorylation up-regulates activity | 8657103 | SIGNOR-246576 |
| EGFR | PLCG1 | Tyr783 | EGRNPGFyVEANPMP | phosphorylation up-regulates | 9176240 | SIGNOR-48872 |
| HCK | PLCG1 | Tyr1253 | EGSFESRyQQPFEDF | phosphorylation up-regulates activity | 7682059 | SIGNOR-249360 |
| HCK | PLCG1 | Tyr783 | EGRNPGFyVEANPMP | phosphorylation up-regulates activity | 7682059 | SIGNOR-249362 |
| EGFR | PLCG1 | Tyr771 | IGTAEPDyGALYEGR | phosphorylation up-regulates | 1689310 | SIGNOR-20984 |
| EGFR | PLCG1 | Tyr472 | KLAEGSAyEEVPTSM | phosphorylation up-regulates | 1689310 | SIGNOR-20980 |
| ITK | PLCG1 | – | phosphorylation up-regulates | 20519342 | SIGNOR-165803 | |
| LYN | PLCG1 | Tyr771 | IGTAEPDyGALYEGR | phosphorylation up-regulates activity | 7682059 | SIGNOR-249381 |
| SRC | PLCG1 | Tyr783 | EGRNPGFyVEANPMP | phosphorylation up-regulates activity | 7682059 | SIGNOR-247316 |
| ABL1 | PLCG1 | Tyr1003 | KGKKFLQyNRLQLSR | phosphorylation down-regulates activity | 12652307 | SIGNOR-276002 |
| BTK | PLCG1 | – | phosphorylation up-regulates activity | 31431692 | SIGNOR-279444 | |
| PTPRJ | PLCG1 | – | dephosphorylation unknown | 11259588 | SIGNOR-248706 | |
| LYN | PLCG1 | Tyr783 | EGRNPGFyVEANPMP | phosphorylation up-regulates activity | 7682059 | SIGNOR-249382 |
| HCK | PLCG1 | Tyr771 | IGTAEPDyGALYEGR | phosphorylation up-regulates activity | 7682059 | SIGNOR-249361 |
| PDGFRB | PLCG1 | – | phosphorylation up-regulates | 7535778 | SIGNOR-28179 | |
| ABL1 | PLCG1 | Tyr771 | IGTAEPDyGALYEGR | phosphorylation down-regulates activity | 12652307 | SIGNOR-276001 |
| NTRK1 | PLCG1 | – | phosphorylation up-regulates | 8384556 | SIGNOR-38538 | |
| EGFR | PLCG1 | Tyr1253 | EGSFESRyQQPFEDF | phosphorylation up-regulates | 1689310 | SIGNOR-20976 |
| PRKCA | PLCG1 | Ser1248 | HGRAREGsFESRYQQ | phosphorylation down-regulates | 1370476 | SIGNOR-17905 |
| PRKD1 | PLCG1 | Ser1248 | HGRAREGsFESRYQQ | phosphorylation down-regulates activity | 1370476 | SIGNOR-248846 |
| PDGFRA | PLCG1 | – | phosphorylation up-regulates | 7535778 | SIGNOR-28176 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SYK | phosphorylation up-regulates → | PLCG1 PTyr771 | phosphorylation up-regulates → | PLCG1 | 8657103 | SIGNOR-246572 |
| PRKACA | phosphorylation up-regulates → | PLCG1 PSer1248 | phosphorylation down-regulates ⊣ | PLCG1 | 1370476 | SIGNOR-17901 |
| SYK | phosphorylation up-regulates → | PLCG1 PTyr783 | phosphorylation up-regulates → | PLCG1 | 8657103 | SIGNOR-246576 |
| EGFR | phosphorylation up-regulates → | PLCG1 PTyr783 | phosphorylation up-regulates → | PLCG1 | 9176240 | SIGNOR-48872 |
| HCK | phosphorylation up-regulates → | PLCG1 PTyr1253 | phosphorylation up-regulates → | PLCG1 | 7682059 | SIGNOR-249360 |
| HCK | phosphorylation up-regulates → | PLCG1 PTyr783 | phosphorylation up-regulates → | PLCG1 | 7682059 | SIGNOR-249362 |
| EGFR | phosphorylation up-regulates → | PLCG1 PTyr771 | phosphorylation up-regulates → | PLCG1 | 1689310 | SIGNOR-20984 |
| EGFR | phosphorylation up-regulates → | PLCG1 PTyr472 | phosphorylation up-regulates → | PLCG1 | 1689310 | SIGNOR-20980 |
| LYN | phosphorylation up-regulates → | PLCG1 PTyr771 | phosphorylation up-regulates → | PLCG1 | 7682059 | SIGNOR-249381 |
| SRC | phosphorylation up-regulates → | PLCG1 PTyr783 | phosphorylation up-regulates → | PLCG1 | 7682059 | SIGNOR-247316 |
| ABL1 | phosphorylation up-regulates → | PLCG1 PTyr1003 | phosphorylation down-regulates ⊣ | PLCG1 | 12652307 | SIGNOR-276002 |
| LYN | phosphorylation up-regulates → | PLCG1 PTyr783 | phosphorylation up-regulates → | PLCG1 | 7682059 | SIGNOR-249382 |
| HCK | phosphorylation up-regulates → | PLCG1 PTyr771 | phosphorylation up-regulates → | PLCG1 | 7682059 | SIGNOR-249361 |
| ABL1 | phosphorylation up-regulates → | PLCG1 PTyr771 | phosphorylation down-regulates ⊣ | PLCG1 | 12652307 | SIGNOR-276001 |
| EGFR | phosphorylation up-regulates → | PLCG1 PTyr1253 | phosphorylation up-regulates → | PLCG1 | 1689310 | SIGNOR-20976 |
| PRKCA | phosphorylation up-regulates → | PLCG1 PSer1248 | phosphorylation down-regulates ⊣ | PLCG1 | 1370476 | SIGNOR-17905 |
| PRKD1 | phosphorylation up-regulates → | PLCG1 PSer1248 | phosphorylation down-regulates ⊣ | PLCG1 | 1370476 | SIGNOR-248846 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SYK | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-246572 |
| PTPRF | dephosphorylation down-regulates | PLCG1 | SIGNOR-85166 |
| EPHA2 | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-279708 |
| PRKACA | phosphorylation down-regulates | PLCG1 | SIGNOR-17901 |
| PTPRJ | dephosphorylation down-regulates | PLCG1 | SIGNOR-105790 |
| NTRK2 | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-279241 |
| SYK | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-246576 |
| EGFR | phosphorylation → up-regulates | PLCG1 | SIGNOR-48872 |
| HCK | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-249360 |
| HCK | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-249362 |
| EGFR | phosphorylation → up-regulates | PLCG1 | SIGNOR-20984 |
| EGFR | phosphorylation → up-regulates | PLCG1 | SIGNOR-20980 |
| ITK | phosphorylation → up-regulates | PLCG1 | SIGNOR-165803 |
| LYN | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-249381 |
| SRC | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-247316 |
| ABL1 | phosphorylation → down-regulates activity | PLCG1 | SIGNOR-276002 |
| BTK | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-279444 |
| PTPRJ | dephosphorylation → unknown | PLCG1 | SIGNOR-248706 |
| LYN | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-249382 |
| HCK | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-249361 |
| PDGFRB | phosphorylation → up-regulates | PLCG1 | SIGNOR-28179 |
| ABL1 | phosphorylation → down-regulates activity | PLCG1 | SIGNOR-276001 |
| NTRK1 | phosphorylation → up-regulates | PLCG1 | SIGNOR-38538 |
| EGFR | phosphorylation → up-regulates | PLCG1 | SIGNOR-20976 |
| PRKCA | phosphorylation down-regulates | PLCG1 | SIGNOR-17905 |
| PRKD1 | phosphorylation → down-regulates activity | PLCG1 | SIGNOR-248846 |
| PDGFRA | phosphorylation → up-regulates | PLCG1 | SIGNOR-28176 |