| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | PLCG1 | Tyr771 | IGTAEPDyGALYEGR | phosphorylation down-regulates activity | 12652307 | SIGNOR-276001 |
| SYK | PLCG1 | Tyr771 | IGTAEPDyGALYEGR | phosphorylation up-regulates activity | 8657103 | SIGNOR-246572 |
| EGFR | PLCG1 | Tyr771 | IGTAEPDyGALYEGR | phosphorylation up-regulates | 1689310 | SIGNOR-20984 |
| LYN | PLCG1 | Tyr771 | IGTAEPDyGALYEGR | phosphorylation up-regulates activity | 7682059 | SIGNOR-249381 |
| HCK | PLCG1 | Tyr771 | IGTAEPDyGALYEGR | phosphorylation up-regulates activity | 7682059 | SIGNOR-249361 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | phosphorylation up-regulates → | PLCG1 PTyr771 | phosphorylation down-regulates ⊣ | PLCG1 | 12652307 | SIGNOR-276001 |
| SYK | phosphorylation up-regulates → | PLCG1 PTyr771 | phosphorylation up-regulates → | PLCG1 | 8657103 | SIGNOR-246572 |
| EGFR | phosphorylation up-regulates → | PLCG1 PTyr771 | phosphorylation up-regulates → | PLCG1 | 1689310 | SIGNOR-20984 |
| LYN | phosphorylation up-regulates → | PLCG1 PTyr771 | phosphorylation up-regulates → | PLCG1 | 7682059 | SIGNOR-249381 |
| HCK | phosphorylation up-regulates → | PLCG1 PTyr771 | phosphorylation up-regulates → | PLCG1 | 7682059 | SIGNOR-249361 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ABL1 | phosphorylation → down-regulates activity | PLCG1 | SIGNOR-276001 |
| SYK | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-246572 |
| EGFR | phosphorylation → up-regulates | PLCG1 | SIGNOR-20984 |
| LYN | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-249381 |
| HCK | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-249361 |
