| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SYK | PLCG1 | Tyr783 | EGRNPGFyVEANPMP | phosphorylation up-regulates activity | 8657103 | SIGNOR-246576 |
| EGFR | PLCG1 | Tyr783 | EGRNPGFyVEANPMP | phosphorylation up-regulates | 9176240 | SIGNOR-48872 |
| HCK | PLCG1 | Tyr783 | EGRNPGFyVEANPMP | phosphorylation up-regulates activity | 7682059 | SIGNOR-249362 |
| SRC | PLCG1 | Tyr783 | EGRNPGFyVEANPMP | phosphorylation up-regulates activity | 7682059 | SIGNOR-247316 |
| LYN | PLCG1 | Tyr783 | EGRNPGFyVEANPMP | phosphorylation up-regulates activity | 7682059 | SIGNOR-249382 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SYK | phosphorylation up-regulates → | PLCG1 PTyr783 | phosphorylation up-regulates → | PLCG1 | 8657103 | SIGNOR-246576 |
| EGFR | phosphorylation up-regulates → | PLCG1 PTyr783 | phosphorylation up-regulates → | PLCG1 | 9176240 | SIGNOR-48872 |
| HCK | phosphorylation up-regulates → | PLCG1 PTyr783 | phosphorylation up-regulates → | PLCG1 | 7682059 | SIGNOR-249362 |
| SRC | phosphorylation up-regulates → | PLCG1 PTyr783 | phosphorylation up-regulates → | PLCG1 | 7682059 | SIGNOR-247316 |
| LYN | phosphorylation up-regulates → | PLCG1 PTyr783 | phosphorylation up-regulates → | PLCG1 | 7682059 | SIGNOR-249382 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SYK | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-246576 |
| EGFR | phosphorylation → up-regulates | PLCG1 | SIGNOR-48872 |
| HCK | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-249362 |
| SRC | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-247316 |
| LYN | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-249382 |
