| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | PLCG1 | Tyr1253 | EGSFESRyQQPFEDF | phosphorylation up-regulates | 1689310 | SIGNOR-20976 |
| HCK | PLCG1 | Tyr1253 | EGSFESRyQQPFEDF | phosphorylation up-regulates activity | 7682059 | SIGNOR-249360 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | phosphorylation up-regulates → | PLCG1 PTyr1253 | phosphorylation up-regulates → | PLCG1 | 1689310 | SIGNOR-20976 |
| HCK | phosphorylation up-regulates → | PLCG1 PTyr1253 | phosphorylation up-regulates → | PLCG1 | 7682059 | SIGNOR-249360 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EGFR | phosphorylation → up-regulates | PLCG1 | SIGNOR-20976 |
| HCK | phosphorylation → up-regulates activity | PLCG1 | SIGNOR-249360 |
