| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | PLCG1 | Ser1248 | HGRAREGsFESRYQQ | phosphorylation down-regulates | 1370476 | SIGNOR-17905 |
| PRKD1 | PLCG1 | Ser1248 | HGRAREGsFESRYQQ | phosphorylation down-regulates activity | 1370476 | SIGNOR-248846 |
| PRKACA | PLCG1 | Ser1248 | HGRAREGsFESRYQQ | phosphorylation down-regulates | 1370476 | SIGNOR-17901 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | PLCG1 PSer1248 | phosphorylation down-regulates ⊣ | PLCG1 | 1370476 | SIGNOR-17905 |
| PRKD1 | phosphorylation up-regulates → | PLCG1 PSer1248 | phosphorylation down-regulates ⊣ | PLCG1 | 1370476 | SIGNOR-248846 |
| PRKACA | phosphorylation up-regulates → | PLCG1 PSer1248 | phosphorylation down-regulates ⊣ | PLCG1 | 1370476 | SIGNOR-17901 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation down-regulates | PLCG1 | SIGNOR-17905 |
| PRKD1 | phosphorylation → down-regulates activity | PLCG1 | SIGNOR-248846 |
| PRKACA | phosphorylation down-regulates | PLCG1 | SIGNOR-17901 |
